| Project/Area Number |
12670936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
KAZUHIEO shinosaki Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (40215984)
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| Co-Investigator(Kenkyū-buntansha) |
MASATOSHI takeda Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 (00179649)
SATOSHI ukai Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (80324763)
TAKASHI nishikawa Osaka University Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (60273629)
山下 仰 大阪大学, 医学系研究科, 講師 (50294054)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Schizophrenia / Hallucination / DLPFC (dorsolateral prefrontal cortex) / MEG (maenetoencephalography) / STG (superior temporal gyrua) / neuroimaging / Parallel distributed processing / hypofrontality / 統合失調症 / 前頭前野 / 聴覚野 / ネットワーク / しりとり / スツループ課題 / 精神分裂病 / 脳磁図MEG / 認知 / stroop課題 / 語産生課題 / ウエルニッケ領野 / NIRS / DLPFC / 神経回路 / 精神科リハビリテーション / Stroop課題 |
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| Research Abstract |
Parallel-distributed processing neuroimaging was studied in normal control, schizophrenic patients with auditory hallucination (AH) and without AH by using MEG (magnetoencephalography) and synthetic aperture magnetometry (SAM) analysis. In the Stroop color word interference task, the total reaction time was set at 650ms with a time window of 20ms in steps of 50ms. Neural activation began in the left posterior parietal-occipital area (150-250 ms post-stimulus), followed by the right prefrontal polar area (250-350 ms), the left dorsolateral prefrontal cortex (DLPFC, 250-400 ms), and the mid-to lower-primary motor area (350-400 ms). Successive and temporally overlapping activation of various cortical regions were successfully estimated with a short 200 ms time interval, contrary to previous PET and fMRI studies. The left DLPFC in patients without AH showed smaller activation than that in the control group. The left DLPFC in patients with AH showed no significant activation. These results were consistent with the hypofrontality hypothesis in schizophrenic patients and showed that dysfunction in the left DLPFC in schizophrenia with AH might be more remarkable than that in schizophrenia without AH. In word generation (Shiritori) task, significant activation in the left DLPFC was estimated in all patients, while not in most of controls. Significant activation in the left posterior superior temporal gyrus (STG) was estimated in most of controls, while not in any patients. These results showed the functional impairment between the linguistic process in the STG and the organization-control process in the DLPFC in schizophrenic patients.
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