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COGNITIVE FUNCTION OF HEREDITARY HIGH RISK GROUP OF SCHIZOPHRENIA USING EVENT-RELATED POTENTIAL (ERP) AND FUNCTIONAL NEAR INFRARED SPECTROSCOPY (f-NIRS).

Research Project

Project/Area Number 12670949
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

OGURA Chikara  University of the Ryukyus, School of Medicine, Department of NEUROPSYCHIATRY, Professor, 医学部, 教授 (60032330)

Co-Investigator(Kenkyū-buntansha) HIRAMATSU Ken-ichi  University of the Ryukyus, School of Medicine, Department of NEUROPSYCHIATRY, Assistant Professor, 医学部, 助教授 (50218814)
HUKUJI Yasuhide  University of the Ryukyus, School of Medicine, Department of NEUROPSYCHIATRY, Instructor, 医学部, 助手 (00311887)
HOKAMA Hiroto  University of the Ryukyus, School of Medicine, Department of NEUROPSYCHIATRY, Instructor, 医学部, 助手 (80238724)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
KeywordsSchizophrenia / ERPs / f-NIRS / Hereditary risk / LORETA / 遺伝
Research Abstract

This research project examined cognitive function of hereditary high risk group of schizophrenia using event-related potential (ERP) and functional near infrared spectroscopy (f-NIRS). In the event-related potential (ERPs) study. ERPs were examined in 10 schizophrenic subjects (8 male, 2 female, 30.0 +/- 6.1 y.o.), 10 sex matched their siblings (28.8 +/- 2.4 y.o.) and sex-age matched 10 healthy controls (29.0 +/- 3.2 y.o.). ERPs were recorded during an auditory oddball task. Schizotypal Personality Questionnaire (SPQ) was evaluated and correlation of SPQ. Score and ERP results was investigated in sibling group. (Result) 1. Reduced P300 amplitude was found in sibling group as well as schizophrenic group compared to controls. P300 latency did not differ from controls. 2. Positive correlation of P300 amplitude between schizophrenics and their siblings at Pz electrode was found (r = 0.70, p<0.05). 3. Negative correlation between P300 amplitude at Fz electrode and SPO_score was found in sibling group (r = -0.64, p<0.05). 3. LORETA (Low Resolution Electro -magnetic Tomography) analysis of P300 showed reduced cortical current density distribution in the right frontal and bilateral temoral region in both schizoprenics and their siblings compared to controls. In the comparison of schizophrenics and siblings, although both group showed similar cortical current distribution, reduction of current density was notified in the left frontal pole region in schizophrenia compared to siblings. In addition f-NIRS (functional Near Infrared Spectroscopy) examination was undertaken in sibling of schizophrenia showing potential usefulness of f-NIRS to investigate biological substrate of schizophrenia.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 田中晋, 外間宏人, 王継軍, 安里尚彦, 平松謙一: "分裂病者の事象関連電位(ERPs)P300発生源の治療による変化-Current Density Analysisを用いて-"臨床神経生理学. 29巻2号. 144-145 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 福治康秀, 備瀬哲弘, 外間宏人, 平松謙一, 小椋力: "精神分裂病における近赤外線分光法(NIRS)を用いた前頭部の血流変化について"INNERVISION. 16巻6号. 81 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 豊里明, 福治康秀, 外間宏人, 平松謙一, 小椋力: "精神分裂病前駆状態から6年後に精神分裂病と確定診断された1症例における事象関連電位の経時的変化"臨床神経生理学. 29巻2号. 146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 備瀬哲弘, 福治康秀, 外間宏人, 平松謙一, 小椋力: "精神分裂病者のWisconsin Card Sorting Test中に見られた脳血液量変化24チャンネル近赤外線分光法(NIRS)を用いて"臨床神経生理学. 29巻2号. 186 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Fukuji, T.Bise, H.Hokama, K.Hiramatu, C.Ogura: "Changes of cerebral blood volume in frontal region during mirror drawing task measured by two channel NIRS in Sehizophrenics"International Congress Seiries(出版予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetuhiro Bise, Yasuhide Hukuji, Hiroto Hokama, Ken-Ichi Hiramatsu, Chikara Ogura: "Cerebral hemodynamics during Wisconsin Card Sorting Task in schizophrenia using 24 channel f-NlRS"Rinshow-shinkei seirigaku. 29 (2). 186 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Toyozato, Yasuhide Hukuji, Hiroto Hokama, Ken-Ichi Hiramatsu, Chikara Ogura: "ERPs study of a case of schizophrenia following a five-year prodromal period"Rinshow-shinkei seirigaku. 29(2). 146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shin Tanaka, Hiroto Hokama, Wang Jijun, Naohiko Asato, Ken-Ichi Hiramatsu: "P300 change after treatment in schizophrenia using cortical current density analysis"Rinshow-shinkei seirigaku. 29(2). 144-145 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhide Fukuji, Tetuhiro Bise, Hiroto Hokama, Ken-Ichi Hiramatsu, C. Ogura: "Changes of cerebral blood volume in frontal resion during mirror drawing task measured by two channel NIRS in Schizophrenics."International Congress Seiries. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Fukuji, T.Bise, H.Hokama K.Hiramatu, C.Ogura: "Changes of cerebral blood volume in frontal region during mirror drawing task measured by two channel NIRS in Schizophrenics."International Congress Seiries. (出版予定).

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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