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The therapeutic effect of vaccination on neuronal change in animal models with Alzheimer disease

Research Project

Project/Area Number 12670960
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

TADOKORO Mamoru  St. Marianna University, School of Medicine Pathology, Professor, 医学部, 教授 (80081644)

Co-Investigator(Kenkyū-buntansha) ABE Mitsubumi  St. Marianna University, School of Medicine Pathology, Assistant Professor, 医学部, 講師 (30231971)
SAKIYAMA Takeshi  St. Marianna University, School of Medicine Pathology, Associate Professor, 医学部, 助教授 (20130510)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsAlzheimer disease / amvloid plague / amyloid-β-peptide / model mouse
Research Abstract

It has recently been reported that amyloid injection (vaccine) into PDAPD mice resulted in marked decrease of amyloid plaque deposition (APD), although it is uncertain whether or not amyloid plaque is the real cause of Alzheimer disease. Amyloid- β -peptide injection into animal models of Niemann-Pick disease type C (NPC) mice (spm, NIH) and Down syndrome (Dn) mice was projected in that whether or not such vaccination effects the brain tissue with APD and neurofibril change, APD itself is responsible for Alzheimer's etiology, and vaccine is an effective therapy. The pathological difference is only slight between NPC-spm and NPC-NIH mice, but the life span is shorter in NIH mice. We then vaccinated spm mice every 2 weeks. The clinical manifestation and life span were not different from non-vaccined mice. Neurologically, glial reaction of astrocytea was slightly affected in vaccinated mice. To evaluate the long span effect, Dn mice were vaccinated up to 10 months (8 month vaccination). Neural atrophy in cerebral cortex and hippocampus was progressive from 4 -month-old mouse to 10 -month-old mouse. Ten- month-old mouse showed calcification in pallidum and gliosis in basal forebrain. However, gliosis in cerebral subcortex of white matter, stained with GFAP was milder.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 河村 英博, 田所 衛 他: "明らかな心筋症状,知能遅滞をみないLysosomal glycogen storage disease with normal acid maltaseの一例"臨床神経学. 40・3. 259-262 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 田島 千秋, 田所 衛 他: "Cyclophosphamide静注パルス療法が著効した肥厚牲脳硬膜炎の1症例"神経治療. 17・2. 167-171 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Sakiyama, M Tadokoro et al.: "The correlative disturbance of glia in neuronal dyesfunction"NEUROPATHOLOGY. 19・2. A37 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T Sakiyama, M Tadokoro et al.: "The effect of BMT for the clearance of degenerated material in the CNS of Niemann-Pick disease type C"NEUROPATHOLOGY. 20・2. A56 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 川名 裕, 崎山 武志 他: "ムコ多糖症VI型のモデルラットに対する骨髄移植の効果"聖マリアンナ医大誌. 29・5. 459-468 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H Orimo, T Sakiyama et al.: "Importance of deletion of T at nucleotide 1559 alkaline phosphatase gene with hypophosphatasia"J Bone Miner Metab. 20. 28-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kawamura,H. et al.: "A case oflysosomal storage disease with normal acid maltase without MR"Clinical Neurology (in Japanese). 40 (3). 259-262 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tajima,C. et al.: "A case of hypertrophic pachy-meningitis improved with CPA pulse therapy"Neurological Therapeutics (in Japanese). 17 (2). 167-171 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jinn,I. et al.: "Diffuse Lewy body disease from 114 cases with Parkinson disease"Clinical Neurology (in Japanese). 40 (4). 329-333 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sakiyama,T. et al.: "The effect of BMT for the clea Ranee in the CNS of Niemann-Pick disease type C"Neuropathlogy. 20 (2). A56 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kawana,Y. et al.: "The effect of BMT on bone in MPS VI model Rat."St. Marianna Med.J.. 29 (5). 459-468 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugihara,H. et al.: "An autopsy case of hemilaterally dominant border zone infarction"Neuropathology. 21 (4). 278-287 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki,H. et al.: "A case of anaplastic ganglio-glioma with sarcomatous component"Neuropathology. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 河村 英博, 田所 衛他: "明らかな心筋症状,知能発達遅滞をみないLysosomal glycogen storage disease with normal acid maltaseの一例"臨床神経学. 40・3. 259-262 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugihara H, Tadokoro M et al.: "An autopsy case of hemilaterally dominant and Systematic extensive border zone infarction"Neuropathology. 21・4. 278-287 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki H, Tadokoro M et al.: "A case of anaplastic ganglioglioma with sarcomatous component"Neuropathology. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 川名 裕, 崎山 武志他: "ムコ多糖症VI型のモデルラットに対する骨髄移植の効果"聖マリアンナ医大誌. 29・5. 459-468 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Orimo H, Sakiyama T et al.: "Importance of deletion of T at nucleotide 1559 alkaline phosphatase gene with hypophosphatasia"J Bone Miner Metab. 20. 28-33 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 河村英博,田所衛 他: "明らかな心筋症状,知能遅滞をみないLysosomal glycogen storage disease with normal acid maltaseの一例"臨床神経学. 40・3. 259-262 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 田島千秋,田所衛 他: "Cyclophosphamide静注パルス療法が著効した肥厚性脳硬膜炎の1症例"神経治療. 17・2. 167-171 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T Sakiyama,M Tadokoro et al: "The correlative disturbance of glia in neuronal dysfunction"NEUROPATHOLOGY. 19・2. A37 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] T Sakiyama,M Tadokoro et al: "The effect of BMT for the clearance of degenerated material in the CNS of Niemann-Pick disease type C"NEUROPATHOLOGY. 20・2. A56 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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