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Phypiology and pathophysiology of Na-HCO3 cotransporter

Research Project

Project/Area Number 12671024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

SEKI George  Faculty of Medicin, The University of Tokyo, Assistant, 医学部・附属病院, 助手 (30206619)

Co-Investigator(Kenkyū-buntansha) NOIRI Eisei  Faculty of Medicin, The University of Tokyo, Assistant, 医学部・附属病院, 助手 (00301820)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsNBC-1 / RTA / Cataracts / glaucoma / band keratepathy / hand keratopathy / ナトリウム重炭酸共輸送体 / 近位尿細管性アシドーシス / 白内障 / 緑内障 / 帯状角膜変性症
Research Abstract

Mutations in Na-HCO3 cotransporter (NBC-1) cause proximal renal tubular acidosis with ocular abnormalities. We have examined the localization of NBC-1 in the eye, and found that NBC-1 is present in the corneal endothelium, ciliary epithelium, trabecular meshwork, and lens epithelium. We also found NBC-1 activity in human lens epithelial cells. These findings could explain the occurrence of ocular abnormalities associated with NBC-1 inactivation.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Kanimi M et al.: "Incubation in tissue culture media allows isolated rabbit proximal tubules to regain in-vivo-like transport function"Pflugers Arch Eur J Physiol. 440. 908-917 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hara C, et al.: "Intracellular PH regulatory mechanism in a human renal proximal cell line (HKC-8)"Pflugers Arch Eur J Physiol. 440. 713-720 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kunimi M et al.: "Dopamine inhibits renal Na^+ : HCO_3^-cotransporter in rabbit and normotensive reacts but not in spontaneously hypertensive rats"Kidney Int. 57. 534-543 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Igarashi T et al.: "Novel nonsense mutation in the Na^+/HCO_3^-cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma"J Am Soc Nephrol. 12. 713-718 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Usui T et al.: "Molecular basis of ocular abnormalities associated with Proximal renal tubular acidosis"J Clin Invest. 108. 107-115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sun D et al.: "Quantifying porphobilinogen deaminase mRNA in miorodissoctal nephron segments by a modified RT-PCR"Kidney Int. 61. 336-341 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kinimi M, Muller-Berger S, Hara C, Samarzija I, Seki G, Fromter E.: "Incubation in tissue culture media allows isolated rabbit proximal tubules to regain in-vivo-like transport function : response of HC03-absorption to norepinephrine"Pflugers Arch. Vol. 440. 908-917 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hara C, Satoh H, Usui T, Kunimi M, Noiri E, Tsukamoto K, Taniguchi S, Uwatoko S, Goto A, Racusen LC, Inatomi J, Endou H, Fujita T, SeKi G.: "Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8) : evidence for Na+/H+ exchanger, CI-/HC03- exchanger and Na+-HC03- cotransporter"Pflugers Arch. Vol. 440. 713-720 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kunimi M, SeKi G, Hara C, Taniguchi S, Uwatoko S, Goto A, Kimura S, Fujita T.: "Dopamine inhibits renal Na+ : HC03- cotransporter in rabbits and normotensive rats but not in spontaneously hypertensive rats"Kidney Int.. Vol. 57. 534-543 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] lgarashi T, Inatomi J, Sekine T, Seki G, Shimadzu M, Tozawa F, Takeshima Y, Takumi T, Takahashi T, Yoshikawa N, Nakamura H, Endou H.: "Novel nonsense mutation in the Na+/HC03- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma"J Am Soc Nephrol. 12. 713-718 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Kara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G.: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest.. Vol. 108. 107-115 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sun D, Seki G, Uwatoko S, Nakao A, Goto A, Fujita T, Kimura S, Taniguchi S.: "Quantifying porphobilinogen deaminase mRNA in microdissected nephron segments by a modified RT-PCR"Kidney Int. 61. 336-341 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] kunimi M, et al.: "Inaupation in tissue culture meda allows isolated rabbit proximd tabules to regain in-vivo-like transport fanction"Pflugers Arch Eur K Physiol. 440. 908-917 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hara C. et al.: "Intracellular pH regulatory mechanism in a human renal parental cell line (HKC-8)"Pflugers Arch Eur K Physiol. 440. 713-720 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kunimi M, et al.: "Dopamin inhibits renad Na^+HCO_3^- cotranspoter in habbit and normotensive rats but not in sportaneously hypertersive rats"Kidney Int. 57. 534-543 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Igarashi T, et al.: "Novel nonsense mutation in the Na^+/HCO_3^- cotransporter gene(SLC4A4) in a patient with permanent isolated proximal revel tabular acidosis and bilaferal glaucoma"J Am Soc. Nephrol. 12. 713-718 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui T, et al.: "Moleaclar basis ocular abnormalities associated with proximal renal tabular acidosis"J Clin Inuest. 108. 107-115 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sun D, et al.: "Quantifying per phobilinogen deaminase nRNA in miorodissoctal nephnon segments by a modified RT-PCR"Kidney Int. 61. 336-341 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kunimi M,Muller-Berger S',Hara C,Samarzija,Seki G,Frimter E: "Incubation in tissue culture media allows isolated rabbit proximal tubules to regain in-vivo-like transport function : response of HCO_3^- absorption to norepinephrine."Pflugers Arch Eur J Physiol.. 440. 908-917 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hara C,Satch H,Usai T,Kunimi M,Noiri E,Tsukamoto K et al.: "Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8) : evidence for Na^+/H^+ exchanger, Cl^-/HCO_3^- exchanger, and Na^+-HCO_3^- cotransporter"Pflugers Arch Eur J Physiol. 440. 713-720 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Igarashi T,Inatomi J,Sekine T,Seki G,Shimadzu M et al.: "A novel nonsense mutation in the Na^+/HCO_3^- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tabular acidosis and bilateral glaucoma"J.Am.Soci.Nephrol.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Igarashi T,Inatomi J,Sekine T,Seki G: "Unraveling the molecular basis for hereditary renal tubular acidosis"Clinical and Experimental Nephrology. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Usai T,Hara M,Satch.H,Moriyana N,Kagaya H et al: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J.Clin.Invest. (in press). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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