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Chronological gene expression profile in acute renal failure using CDNA array method

Research Project

Project/Area Number 12671026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NOIRI Eisei  The Univ. of Tokyo, Dept. of Nephrology & Endocrinology, Assist. Professor, 医学部・附属病院, 助手 (00301820)

Co-Investigator(Kenkyū-buntansha) TOKUNAGA Katsushi  The Univ. of Tokyo, Dept. Human Genetics, Professor & Chairman, 大学院・医学系研究科, 教授 (40163977)
NAKAO Akihide  The Univ. of Tokyo, Dept. Hemodiafiltration, Lecturer, 医学部・附属病院, 講師 (10159056)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsIschemia-reperfusion / Acute renal failure / Human proximal tubular epithelial cells / Hypoxic stress / Macro-array method / non RI / 虚血再灌流腎障害 / 虚血再灌流 / 低酸素-再酸素化 / cDNAアレイ法
Research Abstract

1.Non-RI CDNA array method was established utilizing low cycle RT-PCR.
2.In vitro hypoxia reoxyganetion model was established using human proximal epithelial cells. Time points that distinguish reversible from irreversible damage was determined.
3.Mice renal ischemia-reperfusion model was established as in vivo model.
4.Gene profiles in reversible/irreversible damage from hypoxia reoxyganetion were obtained using non-RI CDNA array.
5.Subgroup of genes that increase expression during reversible phase and decrease in irreversible damage are focused-as the marker genes prophetic of reversibility in in vitro model.
6.Subgroup of genes that increase expression during reversible phase and decrease in irreversible damage are focused as the marker genes prophetic of reversibility in in vivo model.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Goligorsky MS, Brodsky SV, Noiri E: "Nitric oxide in acute renal failure : NOS versus NOS"Kidney Int. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T, Tada T, Brodsky Sv, Tanaka H, Noiri E, Kajiya F, Goligorsky MS: "Intravital videomicroscopy of peritubular capillaries in renal ischemia"Am J Physiol. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noiri E, Nakao A, Uchida K, Tshukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky MS: "Oxidative and nitrosative stress in acute renal ischemia"Am J Physiol. 281. F948-F957 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noiri E, Ozawa H, Fujita T, Nakao A: "Pharmacokinetics of cetirizine in chronic hemodialysis patients"Nephron. 89. 101-104 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kumura S, Nakao A: "Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells"Free Radic Biol Med. 31. 615-623 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest. 108. 107-115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamamoto T, Tada T, Brodsky SV, Tanaka H, Noiri E, Kajiya F, Goligorsky MS: "Intrayital Videomicroscopy of peritubular capillaries in renal ischemia"Am J Physiol Renal Physiol. epub ahead of print. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noiri E, Nakao A, Uchida K, Tsukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky M: "Scavenging of peroxynitrite ameliorates lipid peroxidation and DNA damage in experimental ischemic acute renal failure"Am J Physiol Renal Physiol. 281. F948-F957 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noiri E, Ozawa H, Fujita T, Nakao A: "Pharmacokinetics of cetirizine in chronic hemodialysis patients : multiple-dose study"Nephron. 89. 101-4 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kimura S, Nakao A: "Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells"Free Radio Biol Med. 31. 615-23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G.: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest. 108. 107-15 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goligorsky MS, Brodsky SV, Noiri E: "Nitric oxide in acute renal failure : NOS versus NOS."Kidney Int (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Goligorsky MS, Brodsky SV, Noiri E: "Nitric oxide in acute renal failure : NOS versus NOS"Kidney Int. (In press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto T, Tada T, Brodsky SV, Tanaka H, Noiri E, Kajiya F, Goligorsky MS: "Intervital videomicroscopy of peritubular capillaries in renal ischemia"Am J physiol. (In press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noiri E, Nakao A, Uchida K, Tsukahara H, Ohono M, Fujita T, Brodsky S, Goligorsky MS: "Oxidative and nitrosative stress in acute renal ischemia"Am J Physiol. 281. F948-F957 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noiri E, Ozawa H, Fujita T, Nakao A: "Pharmacokinetics of cetirizine in chronic hemodialysis patients"Nephron. 89. 101-104 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kumura S, Nakao A: "Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells"Free Radic Biol Med. 31. 615-623 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui T, Rara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest. 108. 107-115 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hara C,Satoh H,Usui T,Kunimi M,Noiri E, et al.: "Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8) i evidence for Na^+/H^+exchanger,Cl^-/HCO_3^-exchanger and Na^+-HCO_3^-cotransporter"Pflugers Arch. 440. 713-720 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noiri E,Yokomizo T,Nakoo A, et al: "An in vivo approach showing the chemotactic activity of leukotriene B_4 in acute renal ischemic-reperfusion injury"Proc Natl Acad Sci USA. 97. 823-828 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsukahara H,Noiri E,Jiang M-Z,Hiraoka M,Mayumi M: "Role of nitric oxide in human pulmonary microvascular endothelial cell adhesion"Life Sci. 67. 1-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noiri E,Taguchi J,Nakao A,Fujita T: "MTHFR gene polymorphism as an exacerbation factor of diebetic nephropathy in type 2 diabetes"Diabetes Care. 23. 260 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 野入英世: "急性腎不全の発症機序"小児内科. 32. 856-863 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 野入英世: "急性腎不全と細胞内エネルギー代謝"腎と透析. 49. 359-363 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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