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Analysis of gene profile involved in the progression of renal disease

Research Project

Project/Area Number 12671052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

ENDOH Masayuki  Tokai University, Depepartmento fMdicine, Associate Professor, 医学部, 助教授 (10147134)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsCD34 / MDS / CFU / hematopoietic stem cells / CML / BMT / 半月体 / CD86 / CD4 / メサンギウム
Research Abstract

1. Comprehensive gene expression profile of the adult human renal cortex was investigated using cDNA array hybridization and the results were published in the nephrology journal.
2. Genomic repertoire of human mesangial cells was analyzed comprehensively by cDNA array hybridization and the results were published in the nephrology journal.
3. Adult human liver transcriptome was profiled by cDNA array hybridization to compare it with human kidney and the results were published.
4. Prognostic predictors in idiopathic membranous nephropathy were investigated and the results were published. Most important prognostic predictor of this disorder was demonstrated as cellular infiltration into the interstitium.
5. Co-stimulatory molecules necessary for T cell activation, CD80 and CD86 were expressed strongly around Bowman's capsule with crescent formation where CD4 T cell exist simultaneously in the kidney tissues from patients with RPGN and IgA nephropathy.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 遠藤正之: "慢性糸球体腎炎におけるメサンギウム特異遺伝子"Annual Review 腎臓2000. 58-63 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, et al.: "Comprehensive gene expression profile of the adult human renal cortex : Analysis by cDNA array hybridization"Kidney Int.. 57. 1452-1459 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Imai H, et al.: "Hematopoietic cell transplantation-related nephropathy in Japan"Am. J. Kidney Dis.. 36. 474-480 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, et al.: "Geneomic repertoire of human mesangial cells : Comprehensive analysis of gene expression by cDNA array hybridization"Nephrology. 5. 215-223 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomino Y, et al.: "Measurement of serum lgA and C3 many predict the diagnosis of patients with lgA nephropathy prior to renal biopsy"J Clin Lab Anal. 14. 220-223 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wu Q.et al.: "Analysis of prognostic predictors in idiopathic membranous nephropathy"Am. J. Kidney Dis.. 37. 380-387 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, et al.: "Profiling the adult human livertranscriptome : analysis by cDNA array hybridization"Hepatology. 35. 178-186 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 遠藤正之: "腎疾患診察の実際"治療. 83. 1321-1325 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 遠藤正之: "臨床現場における水・電解質異常の考え方"診断と治療. 89. 1061-1066 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endoh M: "Mesangium specific genes in chronic glomerulonephritis."Annual Review in Nephrology. 2000. 58-63 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, Endoh M, Fadden K, Yamashita H, Kane A, Sakai H and Ritai A: "Comprehensive gene expression profile of the adult human renal cortex: Analysis by cDNA array hybridization"kidney Int. 57. 1452-1459 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Imai H, Oyama Y, Miura AB, Endoh M, Sakai H: "Hematopoietic cell transplantation-related nephropathy in Japan."Am J Kidney Dis. 36. 474-480 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomino y, Suzuki S, Imai H, Saito T, Kawamura T, Yorioka N, Harada T, Yasumoto Y, Kida H, Kobayashi Y, Endoh M, Sato H, Saito K: "Measurement of serum lgA and C3 may predict the diagnosis of patients with lgA nephropathy prior to renal biopsy."J Clin Lab Anal. 14. 220-223 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, Endoh M, Fadden K, Yamashita H, Sakai H, Kurokawa K, Abboud H and Rifai A: "Genomic repertoire of human mesangial cells: comprehensive analysis of gene expression by cDNA array hybridization"Nephrology. 5. 215-223 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wu Q, Jinde K, Nishina M, Tanabe R, Endoh M, Okada Y, Sakai H and Kurokawa K: "Analysis of prognostic predictors in idiopathic membranous nephropathy."Am J Kidney Dis. 37. 380-387 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yano N, Babib NA, Fadden KJ, Yamashita H, Mitry R, Jauregui H, Kane A, Endoh M and Fafai A: "Profiling the adult human liver transcriptome; analysys by cDNA array hybridization."Hepatology. 35. 178-186 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endoh M: "Medical practice of renal disease."Tiryou. 83. 1321-1325 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Endoh M: "How to solve a water-electrolyte disorder in clinical practice."Shindan to Tiryou. 89. 1061-1066 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Wu Q. et al.: "Analysis of prognostic predictors in idiopathic membranous nephropathy"Am J Kidney Dis. 37. 380-387 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yano N.et al.: "Profiling the adult human lixer transcriptome analysis by cDNA array hybridization"Hepatology. 35. 178-186 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 遠藤正之: "腎疾患診療の実際"治療. 83. 1321-1325 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 遠藤正之: "臨床現場における水・電界質異常の考え方"診断と治療. 89. 1061-1066 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 遠藤正之: "慢性糸球体腎炎におけるメサンギウム細胞特異遺伝子"Annual Review腎臓2000. 58-63 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 遠藤正之: "蛋白尿・血尿の診断手順"診断と治療. 88・7. 1066-1071 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Naohirio Yano: "Comprehensive gene expression profile of the adult human renal cortex : Analysis by cDNA array"Kidney International. 57. 1452-1459 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Qing Wu: "Analysis of prognostic predictors in idiopathic membranous nephropathy."American J Kidney Disease. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Naohirio Yano: "The genomic repertoire of human mesangial cells. Comprehensive gene profiling by cDNA array"Nephrology. (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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