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Study on plasma HDL-C concentration and HDL remodeling in CETP genc polymorphism

Research Project

Project/Area Number 12671129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionTokushima Bunri University

Principal Investigator

MURAKAMI Toru  Tokushima Bunri Univ., Faculty of pharmacv. Professor, 薬学部, 教授 (90278028)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Keinosuke  Okatama Univ. Faculty of Pharmacv Professor, 薬学部, 教授 (70131183)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
KeywordsHDL / CETP / Taq IB polymorphism / HL-514 C / T polymorphism / Reverse cholesterol transport / Atheroselerosis / Diabetes Mellitus / Statin / HDL-C / 動脈硬化惹起性 / HDLリモデリング / 高脂血症
Research Abstract

CETP Taq I B B1B1 polymorphism was an important genotype affecting to plasma HDL cholesterol concentration in multiple clinical factors matched subjects. It was shown that the level of plasma HDL-C of the subjects with B1B1 polymorphism was lower about 8% compared with those of B2B2.In diabetic patients, the level of plasma HDL-C of the subjects with B2B2 was higher about 20% compared with those of B1B1.However it was indicated that this result had not always good effects to prevent atherosclerosis. Because in diabetic patients, the ability of cholesterol transport from donor lipoprotein to acceptor lipoproteins is basically decreased. Therefore increased plasma HDL-C level by the inhibitory effect of reverse cholesterol transport will not be contributed to the prevention of atherosclerosis. Our study furthermore indicated that this condition was more enhanced in patients with hypertriglyceridemics and obesity. We concluded that Taq IB B2B2 genotype itself may contribute to the increment of plasma HDL-C concentration but the role of this gene polymorphism concerning the preventive effects for atherosclerosis in diabetics, obese subjects and hypertriglyceridemics was controversial. Recently we found that the effect of HDL-C increment after statin was the strongest in primary hypercholesterolemics with CETP Taq IB B1B1 polymorphism.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Miida T., Ozaki K., Murakami T., Kashiwa T., Yamadera, Tsuda T., Inano K, Okada N.: "Pre βhigh-density lipoprotein(pre β1-HDL)concentration can change with low-density lipoprotein cholesterol(LDL-C)concentration independent of cholesteryl ester transfer protein(CETP)"Clinica Chimica Acta. 292. 69-80 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamazaki Y., Osaka T., Murakami T., Inoue S.: "JTT-501, a New Oral Hypotriglycemic Agent, Reverses Hypertriglyceridemia in Zucker Fatty and Ventromedial Hypothalamus-I esioned Obese Rats"Metab lism. 49(5). 574-578 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miida T., Sakai K, Nakamura Y., Yamaguchi T., Tsuda T., Kashiwa T., Murakami: "Bezafibrate incrcases pre β1-HDL at the expense of HDI 2 in Hypertriglyceridemia"Arterioscler Thromb Vasc Biol. 20. 2428-2433 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida T., Gotoda T., Okubo M., Izuka Y., Ishibashi S., Kojima T., Murakami T., Murase T., Yamada N.: "A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly 188Glu mutaion prevalent worldwide"J Atheroscler Thromb. 7(1). 45-49 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 柏 隆之, 平野 勉, 西岡富美, 村上 透: "肥満者の血清HDLコレステロール濃度に対するCETP遺伝子多型の影響"日本肥満学会誌. 7(3). 95-98 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 木野祐子, 高橋重人, 村上 透, 大坂寿雅, 井上修二: "拘束ストレスによる血糖上昇に対する食餌の影響"日本生理学会誌. 31. 323-333 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 村上 透, 山田信博: "メデイクイックブック(分担執筆)患者さんによくわかる検査手術の説明と生活指導 第二版"金原出版. 10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miida, T.Ozaki, K.Murakami, T.Kashiwa, t.Yamadera, Tsuda, T.Inano, K.Okada, N: "Pre Bhigh-density lipoprotein(pre β1-HDL) concermation can change with low-dersity lipoporotein cholcslerol(LDL-C)concentration independent of cholesteryl ester transfect protein(CETP)"Arcrioscler Thromg Vase Biol. 292. 69-80 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamazaki, Y.Osaka, T.Murakami, T.Inoue, S: "JTT-501, a New oal Hypotriglycemic agent, Reverses Hyperiglyocndenis in Zuckcr Lally and Ventomcdial Hypothalanus-Lesioned Obesr Rat"Metabolisn. 49(5). 574-578 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshida, t.Gotoda, T.Okubo, M.Izuka, y.Ishibashi, S.Kojima, t.Murase, t.Yamada, N.: "A japanese patient with lipoprotein lipase deficiency honozygous for the Gly 188 Gu murtaion prcvalent worldwide."J Athromh. 7(1). 45-49 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miida T., Ozaki K., Murakami T., Kashiwa T., Ymadera.T., Tsuda T., Inano K.: "Pre βhigh-density lipoprotein (preβ1-HDL) concentration can change with low-density lipoproteincholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP)"Clinica Chimica Acta. 292. 69-80 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamazaki Y., Osaka T., Murakami T., Inoue S.: "JIT-501,a New Oral Hypoteiglycemic Agent, Reverses Hyperniglyceridemia in Zucker Fatty and Ventromedial Hypothalamus-I esioned Obese Rats"Metabolism. 49(5). 574-578 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miida T., Sakai K., Nakamura Y., Yamaguchi T., Tsuda T., Kashiwa T., Murakami., Inano: "Bezafibrate increases pre β1-HDL at the expense of HDL2 in Hypertriglyceridemia"Arterioscler Thromb Vase Biol. 20. 2428-2433 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshida T., Gotoda T., Okubo M., Izuka Y., Ishibashi S., Kojima T., Murakami T., Murase T., Yamada N.: "A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly 188Glu mutaion prevalent worldwide"J Atheroscler Thromb. 7(1). 45-49 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柏 隆之, 平野 勉, 西岡富美, 村上 透: "肥満者の血清HDL,コレステロール濃度に対するCETP遺伝子多型の影響"日本肥満学会誌. 7(3). 95-98 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 木野祐子, 高橋重人, 村上 透, 大坂寿雅, 井上峰二: "拘束ストレスによる血糖上昇に対する食餌の影響"日本生理学会誌. 31. 323-333 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 村上 透, 山田信博: "メデイクイックブック(分担執筆)患者さんによくわかる検査手術の説明と生活指導 第二版"金原出版. 10 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Miida T.,Ozaki K.,Murakami T.,Kashiwa T.,Yamadera.,Tsuda T.,Inano K.,Okada N.: "pre β-high-density lipoprotein (preβ1-HDL) concentration can change woth low-density lipoprotein-cholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP)."Clinica Chimica Acta. 292. 69-80 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamazaki Y.,Osaka T.,Murakami T.,Inoue S.: "JTT-501, a New Oral Hypotriglycemic Agent, Hypertriglyceridemia in Zucker Fatty and Ventromedial Hypothalamus-Lesioned Obese Rats."Metabolism. 49(5). 574-578 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Miida T.,Sakai K.,Nakamura Y.,Yamaguchi T.,Tsuda T.,Kashiwa T.,Murakami.,Inano K.,Okada N.: "Bezafibrate increases pre β1-HDL at the expense of HDL2 in Hypertriglyceridemia."Arterioscler Thromb Vasc Biol. 20. 2428-2433 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 西岡富美,村上透: "なぜ高脂血症の治療をすべきなのか"薬局. 51(8). 4-11 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 村上透,山田信博: "糖尿病性血清脂質異常症"Diabetes Frontier. 472-475 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 村上透,山田信博: "動脈硬化と高脂血症リポ蛋白代謝"診断と治療. 88(11). 1982-1988 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 村上透: "ここが知りたいコレステロール"主婦と生活社. 175 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 村上透: "メデイクイックプック患者さんによくわかる薬の説明 第三版"金原出版. 10 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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