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Procurement of the liver graft from the non-heart-beating donor in ICU.

Research Project

Project/Area Number 12671169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka City University

Principal Investigator

HIROHASHI Kazuhiro  Graduate school of Medicine, Osaka City University Asso. Prof., 大学院・医学研究科, 助教授 (00145799)

Co-Investigator(Kenkyū-buntansha) TNAKA Hiromu  Graduate school of Medicine, Osaka City University Res, Assi., 大学院・医学研究科, 助教授 (90275256)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Keywordsliver transplantetion / non-heart- beating donor / adenosine / prostaclandin / CAMP / CGMP / Nituc oxide / 肝血行動態 / adenosine / 肝阻血再灌流障害 / dopamine / amrinone
Research Abstract

The aim of this study was to develop the strategy for procurement and preservation of the liver graft from the non-heart-beating donor in ICU.
First, we investigated the effects of adenosine or prostaglandin El infusion from the hepatic artery, portal vein, and superior mesenteric artery on the hepatic hemodynamics and oxygen metabolism. According to this preliminary study, the suitable dosage of the infusion was determined. Next, we found that the adenosine infusion from the hepatic artery could mitigate the catecholamine-induced liver injury using the dog model that received the dopamine infusion from the portal vein.
The other hand, we found that the intra-portal infusion of adenosine could mitigate the two-hour normothermic hepatic ischemia and reperfusion injury in the dog. We also detected that the intra-portal infusion of prostaglandin El could improve the outcome of the autologous partial liver transplantation with one-hour normothermic and one-hour cold ischemia. Furthermore, we discovered that the phosphodiesterase type III inhibitor enhanced the protective effects of adenosine by cyclic nucleosides and nitric oxide pathways.
We expect that the combined use of these results could improve the outcome of the liver transplantation using the marginal graft from the non-heart beating donor in ICU.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] C.Sakata, et al.: "Effect of intraportal infusion of adenosine on hepatic bilod flow and injury after ischemia and reperfusion of canine liver"Transplant Proceedings. 31. 509-510 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Tanaka, et al.: "Effect of adenosine on dopamine-induced hepatic impairment in the dog model"Transplant Proceedings. 31. 445-446 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.Sakata, et al.: "Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver"Journal of Hepatobiliary Pancreafic Surgery. 7. 78-85 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Katsuragi, et al.: "Combined use of adenosine and amrinone inhibits reperfusion injury of rat liver"Pathophysiology. 8. 29-34 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Katsuragi, et al.: "Phosphodiesterase type III inhibitor enhances the protective effects of adenosine against ischemic hepatic injury in rats"Transplant Proceedings. 33. 976-977 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C. Sakata, H. Tanaka, S. Takemura, Y. Minamiyama, A. Nakamura, K. Katsuragi, H. Huang, S. Kubo, K. Hirohashi, H. Kinoshita: "Effect of intraportal infusion of adenosine on hepatic bllod flow and injury after ischemia and reperfusion of canine liver"Transplant Proceedings. 31. 509-510 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Tanaka, K. Hirohashi, C. Sakata, K. Katsuragi, H. Huang, S. Takemura, T. Tsukamoto, S. Kubo, H. Kinoshita: "Effect of adenosine on dopamine-induced hepatic impairment in the dog model"Transplant Proceedings. 31. 445-446 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C. Sakata, H. Tanaka, S. Takemura, K. Hirohashi, Y. Minamiyama, A. Nakamura, M. Inoue, H. Kinoshita: "Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver"Journal of Hepatobiliary Pancreatic Surgery. 7. 78-85 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Katsuragi, S. Takemura, Y. Minamiyama, H. Tanaka, K. Hirohashi, M. Inoue, H. Kinoshita: "Phosphodiesterase type III inhibitor enhances the protective effects of adenosine against ischemic hepatic injury in rats"PathophysioIogy. 8. 29-34 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Katsuragi, K. Hirohashi, S. Takemura, Y. Minamiyama, H. Tanaka, C. Sakata, Y. Nishino. T. Shuto, S. Kubo, H. Kinoshita: "Phosphodiesterase type III inhibitor enhances the protective effects of adenosine against ischemic hepatic injury in rats"Transplant Proceedings. 33. 976-977 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Katsuragi, K.Hirohashi, S.takemura, et al.: "Phosphodiesterase type III inhibitor enhances the protective effects of adenosine against ischemic hepatic injury in rats"Transplantation Proceedigs. 33. 976-977 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Katsuragi, S.Takemura, Y.Minamiyama, et al.: "Cambined use of adenosine and amurinone inhibits reperfusion injury of rat liver"Pathophysiology. 8. 29-34 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Sakata: "Post-ischemic intraportal adenosine administration protects against reperfusion injury of canine liver"J.Hepatlbiliang Pancreat Surg. 7(1). 78-85 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Tanaka: "Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function "British Journal of Surgery. 87. 879-882 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 塚本忠司: "術後門脈血栓症に対する門脈内ステント留置"日本外科系連合学会誌. 25(4). 692-696 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Takemura: "Nitric oxide synthase inhibitor increases hepatic injury with formation of oxidative DNA damage and microcirculatory disturbance in endotoxemic rats"Hepato-gastroenterology. 47. 1364-1370 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Katsuragi: "Combined use of adenosine and amrinone inhibits reperfusion injury of rat liver"Pathophysiology. (in press). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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