| Project/Area Number |
12671180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Women 's Medical University |
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Principal Investigator |
HIROYUKI Tsukui Tokyo Women 's Medical Univ, Instructor,, 医学部, 助手 (00297508)
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| Co-Investigator(Kenkyū-buntansha) |
YASUO Tomizawa Tokyo Women 's Medical Univ, Instructor,, 医学部, 助手 (00159047)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | taurine / myocardial protection / cardiac surgery / acute phase after surgery / intropic effect / antiarrhythmic effect |
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| Research Abstract |
Effect of oral treatment with taurine in acute phase after cardiac surgery
Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in cardiac tissue, comprising in excess of 50% of the total free amino acid pool. We assessed the hemodynamic effects of oral pretreatment with taurine in the acute phase after cardiac surgery. Twenty-one patients undergoing coronary artery bypass grafting and valve replacement were randomly divided into two groups. Ten patients (Group T) were treated with taurine 3 g/day for seven days, and the remainder (Group C) were not treated before surgery. Biopsy specimens were taken from the right atrium before cross clamping of the aorta and 20 minutes after reperfusion. Taurine concentration of the right atrium in Group T was higher than that in Group C at both time points.
Satisfactory hemodynamics and urine output were observed in Group T, which showed lower levels catecholamines and shorter duration than Group C. Development of ventricular arrhythmias was depressed in Group T. Serum calcium concentration was maintained normally without calcium supplementation in Group T. These results suggest that taurine has the potential to improve hemodynamics as an inotropic agent, an antiarrhythmic drug, and calcium modulator in the acute phase after cardiac surgery.
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