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Experimental and Clinical Studied for process of gastric carcinogenesis

Research Project

Project/Area Number 12671215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionShinshu University

Principal Investigator

SUGIYAMA Atsushi  Shinshu University Hospital, Medical Care Networking Center, Associate Professor, 医学部・附属病院・医療福祉支援センター, 助教授 (90187675)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsgastric cancer / Helicobacter pylori / Phenotype of cancer / promotor effect / duodenogastric reflux / gastric mucin / α-4GnT mRNA / Prostaglandini / α4-GnT遺伝子 / スナネズミ / 発癌のプロモーター / 形質発現 / 腸上皮化生 / ピロリ菌陰性胃癌
Research Abstract

The process of gastric carcinogenesis concerning Helicobacter pylori ( Hp ) was studied, and following results were obtained.
1. In Mongolian gerbil ( MG ) model Hp and chemical carcinogen induce several phenotype of gastric cancer, but intestinal metaplasia may be a direct precursor only in a subset of the intestinal-type tumors.
2. In the relationship between Hp and gastric carcinogenesis, Hp is a promoter rather than an initiator, and other environmental factors ( the timing of carcinogen administration ) play important roles.
3. Hp infection plus duodenogastric reflux increase cell proliferation in the gastric mucosa in MG model.
4. Hp eradication diminishes enhancing effect of Hp infection on glandular stomach carcinogenesis in MGs. Hp eradication may be useful as a prevention approach against stomach cancer.
5. In the early stage of Hp infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents.
6. As results, the expression level of a 4GnT mRNA tended to be increased in the pyloric mucosa with Hp infection, suggesting that Hp infection enhances the biosynthesis of gland mucous cell-type mucin.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Shimizu,N., Ikehara,Y., Inada,K., Nakanishi,H., Tsukamoto,T., Nozaki,K., Kaminishi,M., Kuramoto,S., Sugiyama,A., Katsuyama,T., Tatematsu,M.: "Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils"Cancer Res.. 60. 1512-1514 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maruta,F., Sugiyama,A., Ishida,K., Ikeno,T., Murakami,M., Kawasaki,S., Ota,H., Tatematsu,M., Katsuyama,T.: "Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori"Cancer Letter. 160. 99-105 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu,F., Nakayama,J., Sugiyama,A., Kawasaki,S., Katsuyama,T.: "Gastric grand mucous cells circulate in peripheral blood after endoscopic biopsy of the gastric mucosa"Am J Gastroenterol. 95. 34-35 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu,N., Ikehara,Y., Nozaki,K., Kaminishi,M., Tsuda,H., Sugiyama,A., Katsuyama,T., Tatematsu,M.: "Effects of lactoferrin administation in Helicobacter pylori infection animal model"Lactoferrin: Structure, Function and Applications. K. Shimazaki et al. eds.. Elsevier Science B.V.. 209-215 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugiyama,A., Ikeno,T., Ishida,K., Maruta,F., Murakami,M., Sato,T., Saito,H., Ishizone,S., Kawasaki,S., Ota,H., Katsuyama,T.: "Paradoxical role of Helicobacter pylori infection -protective effect against ethano-induced gastric mucosal injury in Mongolian gerbils-Dig"Dis Sci. 46. 2433-2439 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugiyama,A., Maruta,F., Tsuzuki,S., Murakami,M., Kawasaki,S.: "Distribution of Thymidina Phosphorylase Activity in Gastric Carcinoma and Adjacent Normal Gastric Tissue"Hepato-gastroenterology. in press. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kumagai,T., Yan,J., Graham,DY., Tozuka,M., Okimura,Y., Ikeno,T., Sugiyama,A., Katsuyama,T., Ota,H.: "Serum immunoglobulin G immune response to Helicobacter pylori antigens in Mongolian Gerbils"J Clinical Microbioloy. 39. 1283-1288 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugiyama,A., Ikeno,T., Maruta,F., Kawasaki,S., Hayama,M., Ota,H., Yoshizawa,A., Nakajima,K., Fukushima,M., Honda,H: "Long-term Helicobacter pylori colonization produces G cell hyperplasia and carcinoid tumor"J Cell Mol Med. 4. 308-309 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maruta,F., Ota,H., Genta,M., Sugiyama,A., Tatematsu,M., Katsuyama,T., Kawasaki,S.: "Role of N-methyl-N-nitrosurea in the induction of intestinal metaplasia and gastric adenocarcinoma in Mongolian gerbils infected with Helicobacter pylori"Scand J Gastroenterol. 36. 283-290 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsuzuki,S., Ota,H., Hayama,A., Sugiyama,A., Akamatsu,T., Kawasaki,S.: "Proliferation of α -smooth muscle actin-containing stromal cells ( Myofibroblast ) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus"Scand J Gastroenterol. 35. 86-91 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu N, Sugiyama A et. al: "Eradication diminishes enhaucing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils"Cancer Research. 60. 1512-1514 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Marta F, Sugiyama A et al.: "Timing of N-methyl-N-nitrosourea administration effects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori"Cancer Letter. 160. 99-105 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugiyama A et al.: "Paradoxical role of Helicobacter pylori infection -protective effect against ethanol-induced gastric mucosal injury in Mongolian gerbils"Digestive Diseases and Sciences. 46. 2433-2439 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugiyama A et al.: "Distribution of thymidine phosphorylase activity in gastric carcinoma and adjacent normal gastric tissue"Hepato-gastroenterology. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Marta F, Sugiyama A et al.: "Role of N-methyl-N-nitrosoured in the induction of intestinal metaplasia and gastric carcinoma in Mongolian gerbils infected with Helicobacter pylori"Scandinavian J. of Gastroenterology. 36. 283-290 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 杉山 敦 他: "Helicobacter pylori感染胃粘膜障害に対する十二指腸胃逆流の影響"Ulcer Research. 28. 68-70 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Maruta F,Sugiyama A et al: "Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbil."Cancer Letter. 160. 99-105 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu N,Sugiyama A et al.: "Effects of lactoferrin administration in Helicobacter pylori infection animal model."Lactoferrin : Structure,function and Applications. 2. 209-210 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu N,Sugiyama A et al.: "Eradication diminishes enhansing efects of Helicobacter pylori on glandular stomach carcinogenesis in Mongolian gerbils."Cancer Research. 60. 1512-1514 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu F,Sugiyama A et al.: "Gastric gland mucous cells circulate in peripheral blood after endoscopic biopsy of the gastric mucosa."American Jounal of Gastroenterology. 96. 3017-3018 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maruta F,Sugiyama A et al: "Role of nitrosourea in the induction of intestinal metaplasia and gastric carcinoma in Mongolian gerbils infected with Helicobacter pylori"Scandinavian Journal of gastroenterology. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 丸田福門,杉山敦 ほか: "Helicobacter pylori感染スナネズミにおける胃発癌"消化器科. 30. 16-22 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 杉山敦: "ヘリコバクターピロリフォーラム 分担執筆「化学発癌物質およびH.pylori感染による胃発癌実験」"藤岡榊 編集 医学書院(東京). 88-97 (1999)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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