• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Gene therapy for the liver metastasis of the pancreatic cancer using p53 adenovirus vector

Research Project

Project/Area Number 12671225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

KITAGAWA Toru  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40314322)

Co-Investigator(Kenkyū-buntansha) NISHIDA Toshiro  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40263264)
大山 司  大阪大学, 医学部・附属病院, 医員
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsPancreatic cancer / Liver metastasis / Gene therapy / p53 / Adenovirus vector
Research Abstract

Prognosis of the pancreatic cancer, even if it is resectable, is extremely poor because of the local recurrence or the liver metastasis. Although extended pancreatectomy and intraoperative radiotherapy are effective to the control of the local recurrence, chemotherapy or other conventional therapies are not effective to the liver metastasis. A new therapy including a gene therapy is expected for the treatment of the pancreatic cancer.
The purpose of this study is to evaluate the usefulness of intraportal administration of p53 adenovirus vector for the liver metastases of the pancreatic cancer.
As a result, intraportal administration of p53 adenovirus vector showed antitumor effect to the murine liver metastasis models using tumor cell lines with p53 mutation. Repeated administration of p53 adenovirus vector could enhance the antitumor effect in murine liver metastasis models. On the other hand, using tumor cell lines without p53 mutation, we could not confirm the antitumor effect of intraportal administration of p53 adenovirus vector in the murine liver metastasis models. In additions, any side effect of intraportal administration of p53 adenovirus vector has not been observed in our murine experiments.
With the aim of clinical application of cancer gene therapy to the liver metastasis, we have also examined the intraportal administration of IL-12 transduced fibroblast cells. The antitumor effect to the liver metastasis and the induction of antitumor immunity were confirmed using similar marine liver metastasis models. It is expected that the clinical application of cancer gene therapy would improve the prognosis of the liver metastasis and the quality of life in cancer patients.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Su W, Ito T, Kitagawa T, et al.: "The direct effect of IL-12 on tumor cells : IL-12 acts directly on tumor cells to activate NF-KappaB and enhance IFN-gamma-mediated STATL phosphorylation"Biochem-Biophys-Res-Commun. 280. 503-512 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, Hirota S: "Biological and clinical review of stromal tumors in the gastrointestinal tract"Histology and Histopathology. 15. 1293-1301 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Clinicopathologic features of gastric stromal tumors"J Exp Clin Cancer Res. 19. 417-425 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia"Am-J-Physiol Heart Circ Physiol. 278. H1565-H1570 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Poorly differentiated thyroid carcinoma-What is it. Authors' Response"Am-J-Surg Pathol. 24. 312-313 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Local control in Differentiated thyroid carcinoma with extrathyroidal invasion"Am-J-Surg. 179. 86-91 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Su W, Ito T, Kitagawa T, et al.: "The direct effect of IL-12 on tumor cells : IL-12 acts directly on tumor cells to activate NF-KappaB and enhance IFN-gamma-mediated STAT1 phosphorylation"Biochem-Biophys-Res-Commun. 280. 503-512 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, Hirota S: "Biological and clinical review of stromal tumors in the gastrointestinal tract"Histology and Histopathology. 15. 1293-1301 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Clinicopathologic features of gastric stromal tumors"J Exp Clin Cancer Res. 19. 417-425 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia"Am-J-Physiol Heart Circ Physiol. 278. H1565-1570 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Poorly differentiated thyroid carcinoma -What is it. Authors' Response"Am-J-Surg Pathol. 24. 312-313 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nishida T, et al.: "Local control in Differentiated thyroid carcinoma with extrathyroidal invasion"Am-J-Surg. 179. 86-91 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Su W, Ito T, Kitagawa T, et al.: "The direct effect of IL-12 on tumor cells : IL-12 acts directly on tumor cells to activate NF-KappaB and enhance IFN-gamma-mediated STAT1 phosphorylation."Biochem-Biophys-Res-Commun. 280. 503-512 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishida T, Hirota S: "Biological and clinical review of stromal tumors in the gastrointestinal tract"Histology and Histopathology. 15. 1293-1301 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishida T, et al.: "Clinicopathologic features of gastric stromal tumors"J Exp Clin Cancer Res.. 19. 417-425 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishida T, et al.: "Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia"Am-J-Physiol Heart Circ Physiol. 278. H1565-H1570 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishida T, et al.: "Poorly differentiated thyroid carcinoma-What is it. Authors'Responce"Am-J-Surg Pathol. 24. 312-313 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nishida T, et al.: "Local control in Differentiated thyroid carcinoma with extrathyroidal invasion"Am-J-Surg. 179. 86-91 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Su W,Ito T,Kitagawa T, et al.: "The direct effect of IL-12 on tumor cells : IL-12 acts directly on tumor cells to activate NF-KappaB and enhance IFN-gamma-mediated STAT1 phosphorylation."Biochem-Biophys-Res-Commun. 280. 503-512 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishida T,Hirota S: "Biological and clinical review of stromal tumors in the gastrointestinal tract"Histology and Histopathology. 15. 1293-1301 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishida T, et al.: "Clinicopathologic features of gastric stromal tumors."J Exp Clin Cancer Res.. 19. 417-425 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishida T, et al.: "Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia."Am-J-Physiol Heart Circ Physiol. 278. H1565-1570 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishida T, et al.: "Poorly differentiated thyroid carcinoma-What is it. Authors' Response."Am-J-Surg Pathol. 24. 312-313 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nishida T, et al.: "Local control in Differentiated thyroid carcinoma with extrathyroidal invasion."Am-J-Surg. 179. 86-91 (2000)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi