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aurora 2 is related to lymph node metastasis in colon and gastric carcinoma

Research Project

Project/Area Number 12671232
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

SADANAGA Noriaki  Medical Institute of Bioregulation Kyushu Univ., Research Associate, 生体防御医学研究所, 助手 (20304826)

Co-Investigator(Kenkyū-buntansha) MORI Masaki  Medical Institute of Bioregulation Kyushu Univ., Professor, 生体防御医学研究所, 教授 (70190999)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordscell cycle regulator / aurora 2 / colon cancer / gastric cancer / lymph node metastasis / aurora2 / 消化器癌 / 癌の悪性度
Research Abstract

Backgrounds: Aurora2 is a family of human serine/threonine kinases characterized as cell cycle regulators. In this study, we evaluated the expression of aurora 2 mRNA in gastro-intestinal carcinoma and the correlation between overexpression and clinico-pathological factors. Material and methods: We studied the 201 Japanese patients with carcinoma of gastrointestinal tract, including 53 esophageal cancer, 72 gastric cancer and 76 colorectal cancer. The expression of aurora 2 was investigated by RT-PCR. Results: Aurora 2 mRNA was expressed in 27 of 53 (51%) esophageal cancer, 38 of 72 (53%) gastric cancer and 36 of 76 (46%) colorectal cancer. The relations between the aurora2 expression and the clinicopathological factors was examined. In gastric carcinoma, lymph node metastasis was shown in 27 of 38 (71%) cases with aurora2 expression positive group, more frequent than those with negative expression (p<0.01). In colon carcinoma, lymph node metastasis was present in 23 of 36 (64%) cases with expression positive group and in 7 of 40 (18%) without, a statistically significant difference (p<0.01). There was lymphatic vessel invasion in 25 of 36 (69%) in the aurora2 expression positive group but in only 12 of 40 (30%) in the negative group (p<0.01). There was a significant differences between the two groups in Dukes classification (p<0.01). The overall 5-year survival rate for patients with aurora2 overexpression was lower than for patients without expression in colorectal cancer (92% vs. 64%, p<0.05). Conclusions: These results suggested that aurora2 expression was associated with tumor progression and patients survival and may be a new prognostic indicator for patients with colon carcinoma.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Mori M et al.: "Analysis of the gene-expression profile regarding the progression of human gastric carcinoma"Surgery. 131. 39-47 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al.: "Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma"Cancer Res. 61. 7379-7382 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sadanaga N et al.: "Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas"Clin Cancer Res. 7. 2277-2284 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuyama A et al.: "Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer"Cancer Res. 61. 5714-5717 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al.: "Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma"Int J Cancer. 88. 575-578 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al.: "Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus"Cancer Res. 60. 1177-1182 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al: "Analysis of the gene-expression profile regarding the progression of human gastric carcinoma"Surgery. 131. 39-47 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al: "Absence of Msh2 protein expression is asociated with alteration in the FHITlocus and Fhit protein expression in colorectal carcinoma"Cancer Res. 61. 7379-7382 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sadanaga N etal: "Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas"Clin Cancer Res. 7. 2277-2284 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuyama A et al: "Hepatoma-derived growth factor is associated witn reduced sensitivity to irradiation in esophageal cancer"Cancer Res. 61. 5714-5717 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al: "Prognostic impact of tissue inhibitor of matrix metalloproteinase- 1 in esophageal carcinoma"Int J Cancer. 88. 575-578 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al: "Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus"Cancer Res. 60. 1177-1182 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mori M et al.: "Analysis of the gene-expression profile regarding the progression of human gastric carcinoma"Surgery. 131・1. 39-47 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mori M et al.: "Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma"Cancer Res.. 61・20. 7379-7382 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sadanaga N et al.: "Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas"Clin Cancer Res.. 7・8. 2277-2284 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuyama A et al.: "Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer"Cancer Res.. 61・15. 5714-5717 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mori M et al.: "Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma"Int J Cancer. 88・4. 575-578 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mori M et al.: "Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus"Cancer Res.. 60・5. 1177-1182 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 定永倫明 他: "乳癌における最近の手術と化学療法"外科. 62. 197-202 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sadanaga N et al.: "An adequate treatment for the nipple adenoma."J Surg Oncol. 74. 171-172 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kataoka A. et al.: "RT-PCR detection of breast cancer cells in sentinellymph nodes."Int J Oncol. 16. 1147-1152 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tahara K. et al.: "MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells."Int J Oncol. 17. 805-810 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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