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EVALUATION OF DEFENCE MECHNISM IN ESOPHAGEAL MUCOSA REFLUX ESOPHAGITIS FOLLOWING GASTRECYOMY

Research Project

Project/Area Number 12671243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionYOKOHAMA CITY UNIVERSITY

Principal Investigator

AMANO Tomishige  YOKOHAMA CITY UNIVERSITY, Associate Prof., 医学部・附属病院, 助教授 (20112485)

Co-Investigator(Kenkyū-buntansha) RINO Yasushi  YOKOHAMA CITY UNIVERSITY, Assistant Prof., 医学部・附属病院, 講師 (50254206)
IMADA Toshio  YOKOHAMA CITY UNIVERSITY, Professor, 医学部・附属病院, 教授 (50168514)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
KeywordsReflux Esophagitis / Barrett Esophagus / BrdU labeling index / Apoptosis / Intracellular pH / Eicosanoid
Research Abstract

1) To elucidate reflux esophagitis following total gastrectomy in rats, from the standpoints of cell proliferation and apoptosis as well as macroscopic and histological findings. In results, reflux esophagitis was more frequently and extensively observed in Billroth II anastomosis. BrdU labeling index was increased in esophagitis, while apoptotic index did not change. Trypsin plays an important role in the development of reflux esophagitis after total gastrectomy.
2) To elucidate endoscopic findings and pH monitoring in esophagitis patients following gastrectomy. In results, endoscopic findings was not always correlated with symptoms. The common reflux patterns were alkaline reflux after total gastrectomy, while they were alkaline and acid reflux in subtotal gastrectomy. Barret's esophagus was not observed in patients with esophagitis.
3) To elucidate cell proliferation and expression of Eicosanoid in the esophageal specimen of patients with esophagitis. In results, Ki-67 labeling index was not correlated with esophagitis. Expression rate of Eicosanoid in tissue was almost same between patients with esophagitis and those without esophagitis

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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