| Project/Area Number |
12671263
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
OKA Hisashi School of Medicine, Associate Professor., 医学部, 助教授 (80160654)
|
|---|
| Project Period (FY) |
2000 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | Sonodynamic therapy / Photofrin / colon cancer / CEA |
|---|
| Research Abstract |
The Indication of photodynamic therapy has already been recognized by the clinicalfield but is limited to the early gastric cancer and the early esophagus cancer,and early lung cancer. Ultrasound on the other hand could be used for deeper located lesions and large advanced tumors. In the present study, no adverse side effects were observed by injection of Photofrin and combining ultrasound energy. There was no problem in execution of a change in the skin due to the irradiation of the ultrasound, pain or liver functional disorder. Safety SDT was confirmed.
Comparison of the value of a CEA levels before and after ultrasound irradiation in combination with Photofrin suggests necrotic effect to the tumor. Although decrease in tumor size were not observed by CT, it was postulated that cancer tissue organization was destroyed to some extent. Findings of softening of tumors is an indication of necrosis and longer observation by CT may have led to tumor size reduction. It is believed that SDT was effective in the treatment for the metastasis lesion in the liver of the colon cancer post operation from these results.
Although more investigation is needed to prefect this new treatment by ultrasound, many methods to treat other diseases can be imagined. One future application is for irradiation to small lesions which cannot be removed completely by operation. Development of the device which can irradiate it while actually seeing an ultrasound image maybe very useful for irradiation against small lesions. The approach with a laparoscopy mirror can be expected against the metastasis lesion in the liver. The treatment for hepatoma or breast cancer can be very effective. Combining SDT with an endoscopy may become the answer for future treatment of cancers in various clinical situations.
|
