| Project/Area Number |
12671270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KAMEOKA Shingo Tokyo Women's Medical University, Surgery II, Professor, 医学部, 教授 (80101848)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Wakako Tokyo Women's Medical University, Surgery II, Assistant, 医学部, 助手 (20277172)
SOYAMA Koichi Tokyo Women's Medical University, Surgery II, Assistant, 医学部, 助手 (30266754)
SAITO Noboru Tokyo Women's Medical University, Surgery II, Assistant, 医学部, 助手 (10225724)
板橋 道朗 東京女子医科大学, 医学部, 講師 (10193418)
瀬下 明良 東京女子医科大学, 医学部, 講師 (00171348)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | liver metastasis / pulmonary metastasis / Adhesion molecule / Laminin / Integrin / cytokine / EGF / gene profile analysis / ROC分析 / 細胞外マトリックス / 転移メカニズム |
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| Research Abstract |
We investigated the mechanism and treatment of colorectal cancer with hepatic and pulmonary metastasis. Mainly we approached in that concerned with adhesion molecule. In past history, Laminin, Vitronectin and E-cadherin in 1994-1996, Integrin β1 in 1996-1997, urinary GGH (glucosyl-galactosyl-hydroxylysine) in 1998, MMP-2 and MMP-9 in 1999, were studied.
This study was undertaken to investigate other molecules. Fibronectin, TGF-β, HGF/c-met and EGF. These molecules are related to cancer proliferation. The level of hepatic metastasis group was significantly higher than the no-metastasis group in serum at preoperative stage.
Immunohistochemically, these stain were almost positive in the hepatic metastasis group rather than the no-metastasis group. Recently, we tried to gene profile analysis in order to clarify the relationship between metastasis and adhesion molecule.
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