| Project/Area Number |
12671276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
AKIMARU Koho Nippon Medical School, First Dept. of Surgery, Assistant Professor, 医学部, 助教授 (40142541)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAKATA Atsushi Nippon Medical School, Clinical Fellow, 医学部, 助手
MINETA Shou Nippon Medical School, Clinical Fellow, 医学部, 助手 (70339430)
TAJIRI Takashi Nippon Medical School, Professor, 医学部, 教授 (20163462)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Portal vein / Reconstruction / Peritoneum / Portal vein / Reconstruction / Peritoneum |
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| Research Abstract |
Background : Reconstruction of the portal vein with autologous veins requires extra incisions. Prosthetic material is associated with an increased risk of infection. We therefore created an animal model of portal vein reconstruction using the peritoneum.
Methods : A 2.5 X 2.5 cm piece of the peritoneum was resected from Landrace pigs weighing 30 to 40 kg and was dipped in 100 % alcohol for 10 minutes. The anterior wall of the portal vein measuring 1.2 X 0.6 cm was resected. The peritoneal patch - graft fitting the defect of the portal vein was used to repair it.
Results : All 7 pigs survived the surgery, and were killed at 2, 7, 7, 14, 21, 35 and 49 days, respectively, after surgery. There was no evidence of thrombosis or obstruction of the reconstructed portal vein or any other complications. Complete endothelialization of the patches were noted at day 14.
Conclusions : Our patch - graft technique using the peritoneum is considered to be a good and safe alternative for reconstruction after partial resection of the portal vein in clinical surgery.
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