| Project/Area Number |
12671285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | KURUME UNIVERSITY |
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Principal Investigator |
SUEYOSHI Susumu Kurume University, School of Medicine, Department of Surgery, Lecturer, 医学部, 講師 (30235840)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Hiromasa Kurume University, School of Medicine, Department of Surgery, Professor, 医学部, 教授 (90156878)
SASAHARA Hiroko Kurume University, School of Medicine, Department of Surgery, Assistant, 医学部, 助手 (10279185)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Esophageal Cancer / Endovascular stent graft / Aortic resection / Aorto-esophageal fistula / 動物実験 / 食道大動脈瘻 / 大動脈内ステントグラフト / 大動脈食道瘻 / 大動脈部分切除 |
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| Research Abstract |
1. Purpose : investigate whether aortic stent grafting can be applied in treatment of an esophageal cancer involving the thoracic aorta.
2. Methods : The canine thoracic aorta was partially resected without aorta clamping after emplacement of an endovascular stent graft. Study I ; The aortic whole layer of 1 cm in length and 1/4 of the circumference was resected and was covered by a free fascia patch of the abdominal rectal muscle immediately after stent graft emplacement. Study II ; The aortic adventitia and the outer half of the media of the same size was resected on day 3, 7, 14, 21, and on day 28, after the stent graft emplacement. The resected portion was covered by the free fascia patch in half dogs, and was uncovered in the others. Study III ; The aortic adventitia and the outer half of the media of 1cm in length and 1/2 of the circumference was resected and was uncovered on day 7 after stent graft emplacement. Histological examinations were performed on day 28 and at one year after aortic resection.
3. Results : The aortic wall could be resected in all cases with no complication, except in resection of 1/2 the circumference where the aorta had become narrow. There was no difference in healing of the resected portion of the aorta between with and without fascia covering.
4. Conclusions : An aortic endovascular stent graft could be applied in surgery for an esophageal cancer involving the aorta.
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