• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel system for evaluating the effects of preoperative radiotherapy for rectal cancer

Research Project

Project/Area Number 12671287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

MUTO Tetsuichiro  Japanese Foundation for Cancer Research, Chairman, 癌研究所, 部長 (20110695)

Co-Investigator(Kenkyū-buntansha) HORI Nobukazu  The University of Tokyo, Faculty of Medicine, Associate Surgeon, 医学部, 助手 (90282631)
WATANABE Toshiaki  The University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (80210920)
KATO Yo  Japanese Foundation for Cancer Research, Department of Pathology, Chairman, 癌研究所・病理部, 部長 (20010473)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsrectal cancer / preoperative radiation / intramural spread / tumor deposit / budding / micrometastasis / Ki-67 / P53 / 放射線照射 / 照射前生検 / 免疫組織染色 / 微小転移 / 組織学的効果 / 非照射 / リンパ節転移
Research Abstract

Preoperative irradiation for advanced rectal cancer is known to contribute to tumor down-staging, reduced risk of local recurrence, and improved postoperative survival. The current study compared detailed histopathological findings of tumor invasive margin and regional lymph nodes between lesions after preoperative irradiation and those without preoperative irradiation. In patients who underwent preoperative radiotherapy, irnrnunohistochemical stainings for Ki-67, p53, p21, bcl-2 and caspase 3 were carried out for both biopsy specimens before irradiation and surgically resected specimens after irradiation in order to examine the alterations of these molecular markers caused by preoperative irradiation and to explore the usefulness of these markers in the prediction of effect of preoperative irradiation.
Histopathologically, the length of distal intramural spread was significantly shorter, and tumor deposit in the perirectal fatty tissue and budding at the invasive front were significant … More ly less frequent in irradiated lesions than in non-irradiated lesion. Although lymph node metastasis found with hematoxilin-eosin staining was similar, micrometastasis detectable only with cytokeratin immunohistochemistry was less common in irradiated lesions than in non-irradiated lesions. In the comparisons between biopsy specimens before irradiation and surgically resected specimens after irradiation, Ki-67 labelling index and p53 staining intensity were significantly reduced after irradiation, suggesting that these markers may be useful in the evaluation and prediction of effect of preoperative irradiation.
Clinical impact of histopathological findings and alteration in Ki-67 and p53 is still under examination in the long-term follow-up of patients who underwent preoperative irradiation. In addition, preoperative chemoradiation was commenced at the Cancer Institute Hospital (CIH) in 2002. Histopathological and molecular comparisons between preoperative irradiation and chemoradiation are currently on the way. Less

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report

Research Products

(22 results)

All Other

All Publications

  • [Publications] Muto T: "Randomized controlled trial of lateral node dissection vs. nerve-sparing resection in patients with rectal cancer after preoperative radiotherapy"Diseases of the Colon and Rectum. 44. 1274-1280 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Muto T: "Colorectal cancer statistics in Japan : data from JSCCR registration, 1974-1993"International Journal of Clinical Oncology. 6. 171-176 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Watanabe T: "Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers"Surgery. 132. 27-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 渡辺聡明: "直腸癌に対する放射線療法および化学療法"消化器外科. 26. 343-349 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Muto T: "Multiple primary cancer : An experience at the Cancer Institute Hospital with special reference to colorectal cancer"International Journal of Clinical Oncology. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nagawa H, Muto T, Sunouchi K, Higuchi Y, Tsurita G, Watanabe T, Sawada T,: "Randomized, controlled trial oflateral node dissection vs. nerve-sparing resection in patients with rectal cancer after preoperative radiotherapy."Diseases of the Colon and Rectum. 44-9. 1274-1280 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Muto T, Kotake K, Koyama Y,: "Cobrectal cancer safeties in Japan: data from JSCCR registration, 1974-1993."International Journal of Clinical Oncology. 6-4. 171-176 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] WatanabeT, Tsurita G, Muto T, Sawada T, Sunouchi K, Higuchi Y, Komuro Y, Kanazawa T, Iijima T, Miyaki M, Nagawa H: "Extended lymphadenectomy and preoperative radiotherapy for lower rectal caneos."Smgeiy. 132-1. 27-33 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Watanabe T, Muto T, Nagawva H: "Adjuvant radiotherapy and vhamotherapy for rectal cancer. (in Japanese)"Shoukaki-Geka. 26-3. 343-349 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T: "Multiple primaiy cancer: an experieaice at the Cancer Institute Hospital with special reference to colorectal cancer."International Journal of Clinical Oncology. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Watanabe T: "Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers"Surgery. 132・1. 27-33 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 渡辺 聡明: "直腸・肛門の手術 直腸癌の手術 腹会陰式直腸切断術"消化器外科. 25・7. 992-1001 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 渡辺 聡明: "大腸癌(肝転移を含む)の術中診断"外科. 64・1. 61-66 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 武藤徹一郎: "大腸外科"外科治療. 84(1). 12-15 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 武藤徹一郎: "IBDの外科的治療"日本医師会雑誌. 125(2). 175-180 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Muto: "Colorectal cancer statistics in Japan: data from JSCCR registration, 1974-1993"Iternational Journal of Clinical Oncology. 6(4). 171-176 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 渡辺聡明: "大腸癌自律神経温存直腸切除術"外科. 63(10). 1174-1178 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 渡辺聡明: "直腸癌-進行癌"外科. 63(12). 1484-1489 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 渡辺聡明: "直腸癌の治療(2)放射線治療"外科. 62(1). 81-84 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 渡辺聡明: "大腸癌とMSI(マイクロサテライト不安定性)"臨床医. 26(7). 1686-1688 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤洋: "大腸癌の病理組織診断をめぐって-日・欧米の比較-"臨床医. 26(7). 103-106 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 加藤洋: "大腸鋸歯状腺腫診断の基準と意義"消化器内視鏡. 12(8). 1172-1174 (2000)

    • Related Report
      2000 Annual Research Report

URL: 

Published: 2000-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi