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The therapeutic effect of anti-VEGF neutralizing antibody against carcinomatosa pleuritis

Research Project

Project/Area Number 12671302
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKanazawa University

Principal Investigator

OHTA Yasuhiko  Dept.of Surg(1). Kanazawa Univ. Research Assistant, 医学部・附属病院, 助手 (00272964)

Co-Investigator(Kenkyū-buntansha) TSUNEZUKA Yoshio  Dept. of Surg(1). Kanazawa Univ. Research Assistarnt, 医学部・附属病院, 助手 (80332667)
ODA Makoto  Graduate School of Medical science. Kanazawa Univ. Associate Professor, 大学院・医学系研究科, 講師 (50224241)
呉 哲彦  金沢大学, 医学部・附属病院, 助手 (50313656)
渡辺 俊一  金沢大学, 医学部・附属病院, 助手 (80303303)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsLung cancer / VEGF / Carcinomatosa pleuritis / 胸膜播種 / モデル / ヌードラット / 光力学治療 / PDT
Research Abstract

We assessed the inhibitory effect of anti-vascular eridothelial growth factor (VEGF) neutralizing antibody on the formation of pleural dissemination and pleural effusion using two types of in-vivo model systems. Immune-deficient rats were inoculated with PC-14 cells into (1) a subpieurai space of the parietal pleura after pneumonectomy or (2) into the thoracic cavity directly The rats bearing tumor cells were randomly separated into two groups : non-treatment and treatment with anti-VEGF neutralizing antibody groups. In the treatment group, the antibody was administered at a dose of 250 /μg twice weekly (total 1 mg) from the 7th day after the tiimor inoculation! At the time of the autopsy (4 weeks after the tumor inoculation), all rats developed gross pleural dissemination with/without malignant effusions. In the first model system, despite no significant difference in the mean volume of the primary subpleurai tumors between the groups, the degree of dissemination was suppressed in the treatment group. The immunohistochemical examination showed less tumor vasculature and less frequency of the autocrine motility factor receptor expression in cancer cells at the primary site of the treatment group. In the second model, the inhibitory effect on pleural dissemination was not clear. These results demonstrated the possible association of VEGF with the development of pleural dissemination/metastasis in the context of blood/lymphatic routes and cancer cell motility.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Yasuhiko Ohta: "Clinicopathological and biological assessment of lung cancers with pleural dissemination"Ann. Thorac. Surg.. 69. 1025-1029 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Increased vascular endothelial growth factor and vascular endothelial growth factor-C and decreased nm23 expression associated with microdissemination in the lymph nodes in stage I non-small cell lung cancer"J. Thorac. Cardiovasc Surg. 119. 804-813 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Autocrine motility factor receptor expression associates with tumor progression in thymoma"Int. J. Oncology. 17. 259-264 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Completion pneumonectomy for patients with recurrent lung cancer : the impact of microvessel density on outcome"Surg. Today. 30. 134-138 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Biological characteristics of carcinomatosa pleuritis in orthotopic model systems using immune-deficient rats"Int. J. Oncology. 18. 499-505 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "The predictive value of vascular endothelial growth factor and nm23 for the diagnosis of occult metastasis in non-small cell lung cancer"Jpn. J. Cancer Res.. 92. 361-366 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "The targeting adjuvant brachytherapy in superior sulcus tumor"Surg. Today. 31. 152-155 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Bronchial sleeve resection with complete preservation of the lung for malignant tumors"Respiration. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Can tumor size be a guide for limited surgery for patients with peripheral non-small cell lung cancer?"J. Thorac. Cardiovasc. Surg.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murat Kara: "Autocrine motility factor receptor expression in patients with stage I non-small cell lung cancer"Ann. Thorac. Surg.. 71. 944-948 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Jian Wu: "Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0cm or less in diameter"Ann. Thorac. Surg.. 71. 1772-1778 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Kajita: "The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer"Br. J. Cancer. 85. 255-260 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaya Tamura: "Plasma VEGF concentration can predict the tumor angiogeneci capacity in non-small cell lung cancer"Oncology Reports. 8. 1097-1102 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Results of recent therapy for non-small cell lung cancer with brain metastasis as the initial relapse"Am. J. Clin. Oncol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Lung Cancer : Principles and Practice, Second Edition"Lippincott Williams & Wilkins. 12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Autocrine motility factor receptor expression associates with tumor progression in thymoma."Int J Oncology. 17. 259-264 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Clinicopathological and biological assessment of lung cancers with pleural dissemination."Ann Thorac Surg. 69. 1025-1029 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Increased vascular endothelial growth factor and vascular endothelial growth factor-C and decreased nm23 expression associated with microdissemination in the lymph nodes in stage I non-small cell lung cancer."J Thorac Cadiovasc Surg. 119. 804-813 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Completion pneumonectomy for patients with recurrent lung cancer : The impact ofmicrovessel density on outcome."Surg Today. 30. 134-138 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Current concept of angiogenesis related ot prinary lung cancer"Lung Cancer: Principles and Practice, Second Edition, Chapter II, Lippincott Williams & Wilkins, Philadelphia. 2000. 119-210

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "The predictive value of vascular endothelial growth factor and nm23 fo rthe diagnosis of occult metastasis in non-small cell lung cancer."Jpn J Cancer Res. 92. 361-366 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Murat Kara et al.: "Autocrine motility factor receptor expression in patients with stage I non-small cell lung cancer."Ann Thorac Surg. 71. 944-948 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta et al.: "Biological characteristics of carcinomatosa pleuritis in orthotopic model systems using immune-deficient rats."Int J Oncology. 18. 499-505 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yasuhiko Ohta: "Clinicopathological and biological assessment of lung cancers with pleural dissemination"Ann. Thorac. Surg.. 69. 1025-1029 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Increased vascular endothelial growth factor and vascular endothelial growth factor-c and decreased km23 expression associated with microdissemination in the lymph rodes in stage I non-small cell lung Cancer"J. Thorac. Cardiovase. Surg.. 119. 804-813 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Autocrine motility factor receptor expression associates with tumor progression in thymoma"Int. J. Oncology. 17. 259-264 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Completion pneumonectomy for patients with recurrent lung cancer : The impact of microvessel density on outcome"Surg. Today. 30. 134-138 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Biological Characteristics of carcinomatosa pleuritis in orthotopic model systems using immune-deficient rats"Int. J. Oncology. 18. 499-505 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "The predictive value of vascular endothelial growth factor and nm23 for the diagnosis of occult metastasis in non-small cell lung cancer."Jpn. J. Cancer Res..

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Lung Cancer: Principles and Practice, Second Edition"Lippincott Williams & Wilkins. 12 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Clinicopathological and biological assessment of lung cancers with pleural dissemination"Ann Thorac Surg. 69. 1025-1029 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Increased vascular endothelial growth factor and vascular endothelial growth factor-c and decreased nm23 expression associated with microfissemination in the lymph nodes in stage I non-small cell lung cancer."J Thorac Cardiovasc Surg. 119. 804-813 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Autocrine motility factor receptor expression associates with tumer progression in thymoma"Int.J.Oncol. 17. 259-264 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuhiko Ohta: "The targeting adjuvant brachytherapy in superior sulous tumor"Surg Today. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yasuhiko Ohta: "Lung Cancer Principles and Practice, 2nd ed."Lippincott Williams & Wilkins. 12 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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