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Molecular Biological Approach to Estimate the Effect of Left Ventricular Repair for Chronic Heart Failure

Research Project

Project/Area Number 12671306
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

NISHINA Takeshi  Kyoto University, Graduate school of medicine, Assistant Professor, 医学研究科, 助手 (30314214)

Co-Investigator(Kenkyū-buntansha) SAITO Toshihiko  Kyoto University, Graduate school of medicine, Associate Professor, 医学研究科, 助教授 (30250260)
NIHIURA Kazunobu  Kyoto University, Graduate school of medicine, Associate Professor, 医学研究科, 助教授 (70252450)
KOMEDA Masashi  Kyoto University, Graduate school of medicine, Professor, 医学研究科, 教授 (20303810)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsIschemic cardiomyopathy / Dilated cardiomyopathy / Left ventricular repair / Remodeling / myocardial infarction / Brain natriuretic peptide / endothelin-1 / 心不全 / 外科治療 / 左室形成縮小術 / Dor手術 / Batista手術
Research Abstract

Both ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have a large left ventricular (LV) volume and a high wall tension. As a surgical treatment, LV repair (LVR) for ICM or DCM have been popular to reduce the LV volume. However, the effects of those procedures are not well understood, and we designed animal studies.
LVR for ICM : ICM was developed in rats after anterior descending artery ligation. Rats were divided into LVR group or Sham group. LVR was performed by placating the infracted scar, and Sham operation was just thoracotomy. LV function was evaluated by echocardiography and cardiac catheterization. Brain natriuretic peptide (BNP) mRNA and endothelin-1 (ET-1) mRNA were measured by Nothern blot analysis. One week after surgery, LV motion and size improved in LVR group, and Emax was higher than in Sham group. However, all of them became similar 4 weeks after surgery. BNP mRNA was lower in LVR group at week 1, but not at week 4. ET-1 was higher in LVR group at week 1, but it was similar to that in Sham group at week 4.
LVR for DCM : Dahl rats started an high-salt diet at the age of 7 weeks, and developed DCM about 40 weeks later. The DCM rats were randomized into LVR group or Sham group. LVR was performed by plicating the LV area between the papillary muscle bases. LV function was estimated by echocardiography and catheterization. Right after surgery, LV size decreased and LV motion improved in LVR group. LV re-dilation developed and Emax was the same level between the groups 4 weeks after surgery.
Both in ICM and DCM models, LV size and function improved early after LVR, however, LV remodeling developed in late phase and deteriorated LV function. Prevention of postoperative LV remodeling is important to improve operative results.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Takeshi Nishina: "Initial Effects of the Left Ventricular Repair by Plication May Not Last Long in a Rat Ischemic Cardiomyopathy Model"Circulation. 104 suppl I. I-241-I-245 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sadatoshi Yuasa: "A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy"Journal of Cardiac Surgery. 16. 40-47 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 仁科 健: "虚血性心筋症の外科治療"Cardiovascular Med-Surg. 3. 228-233 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Nishina: "A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery"Journal of Cardiac Surgery. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sadatoshi Yuasa, Takeshi Nishina, Kazunobu Nishimura, Senri Miwa, Tadashi Ikeda, Michiya Hanyu, Yasutada Fujioka, Yasuki Kihara, Shigetake Sasayama, Masashi Komeda: "A Rat Model of Dilated Cardiomyopathy to Investigate Partial Left Ventriculectomy"J Card Surg. 16. 40-47 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Nishina, Kazunobu Nishimura, Sadatoshi Yuasa, Senri Miwa, Takuya Nomoto, Yutaka Sakakibara, Nobuhiro Handa, Ichiro Hamanaka, Yoshahiko Saito, Masashi Komeda: "Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model"Circulation. 104[suppl I]. I-241-I-245 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Nishina, Kazunobu Nishimura, Sadatoshi Yuasa, Senri Miwa, Yutaka Sakakibara, Tadashi Ikeda, Masashi Komeda: "A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery"J Card Surg. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Nishina, Masashi Komeda: "Surgical Treatment of Ischemic Cardiomyopathy"Cadiovascular Med-Surg. 3. 228-233 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshi Nishina: "Initial Effects of the Left Ventricular Repair by Plication May Not Last Long in a Rat Ischemic Cardiomyopathy Model"Circulation. 104 suppl I. I-241-I-245 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sadatoshi Yuasa: "A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy"Journal of Cardiac Surgery. 16. 40-47 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 仁科 健: "虚血性心筋症の外科治療"Cardiovascular Med-Surg. 3. 228-233 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshi Nishina: "A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery"Journal of Cardiac Surgery. (in press).

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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