| Project/Area Number |
12671349
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
NISIZAWA Shigeru Department of Neurosurgry, Hamamatsu Univ Sch of Med, Associate Professor, 医学部, 助教授 (40135257)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOKOTA Naoki Department of Neurosurgry, Hamamatsu Univ Sch of Med, Instructor, 医学部・附属病院, 助手 (00273186)
YOKOYAMA Tetsuo Department of Neurosurgry, Hamamatsu Univ Sch of Med, Associate Professor, 医学部・附属病院, 助教授 (20166896)
NAMBA Hiroki Department of Neurosurgry, Hamamatsu Univ Sch of Med, Professor, 医学部, 教授 (60198405)
TAKEMAE Tadashi Department of technology, Shizuoka University, Professor, 工学部, 教授 (20115356)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | magnetic field / electrical impedance / cerebral circulation / cerebral ischemia |
|---|
| Research Abstract |
We developed new system to measure cerebral blood flow using "tetrapolar circuit method". By using this system, cerebral blood flow can be measured non-invasively, and repeatedly. Furthermore, bilateral cerebral flow can be measured separately, and focused region of interest can also be set.
Before clinical trial, we performed experimental animal study using dogs. Bilateral internal carotid and vertebral arteries were exposed. Bilateral external carotid arteries had been ligated. Before and after ligation of these four arteries, we measured pulse impedance using "tetrapolar circuit method". Just after these experiments, we opened cranial windows bilaterally, and measured cerebral circulation using laser doppler method before and after ligation of these four arteries. The amplitude of pulse impedance, and latency between peak time of pulse impedance and R wave of EKG were correlated well to the results obtained by laser doppler method.
Under these evidence, we applied this system to clinical patients who suffered from cerebral ischemia due to middle cerebral or internal carotid artery occlusion. In the same time, we measured cerebral circulation using single photon emission tomography (SPECT), and compared these results. The data described above in the experimental study using this new system were correlated well to those in SPECT.
These results indicate newly developed our system, "tetrapolar circuit merited" is beneficial for measurement of cerebral circulation in ischemic patients. It is non-invasive, repeatedly applicable, can be easily done at bed-side. We hope this system can replace invasive method for measurement of cerebral circulation.
|
