| Project/Area Number |
12671381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
OHIRA Takayuki Keio University, School of Medicine, Assistant professor, 医学部, 助教授 (40146618)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAGA Kenji Keio University, School of Medicine, Assistant, 医学部, 助手 (70317155)
MIIMI Maki Keio University, School of Medicine, Assistant, 医学部, 助手 (00296609)
KANEKO Yosei Keio University, School of Medicine, Assistant, 医学部, 助手 (40276267)
木村 重人 慶應義塾大学, 医学部・脳神経外科, 助手 (40286498)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Magnetoencephalography / Functional mapping / Verbal generation / SHIRITORI paradigm / Root Mean Square / Brain Mapping / Verbal Learning / Working memory |
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| Research Abstract |
This time we attempted to explore the relation of cognition and word expression in neural perceptual executive system. Healthy right handed 4 normal volunteer (man 2, woman 2) were participated to this study. The magnetic fields while performing capping verses (called "SHIR1TORI" in Japanese) were measured by using magnetoencephalography (MEG). Responses of control session (passive hearing of tone or viewing of flash stimuli, which were used as cue stimuli in the paradigm session) and paradigm session (mental generation of words one by one according to "SHIRITORI" manner immediately after each cue stimulus emission) were recorded, then analyzed after off-line averaging. Root mean square (RMS) of averaged magnetic fields in the paradigm session delineated its increase at some latencies as compared with control one, which latencies after flash and tone stimulus onset ranged from 380msec to 930msec and 300msec to 820msec, respectively. In addition, estimated dipoles of these latencies were located to some language-related area of left hemisphere reported conventional PET and fMRI studies, including frontal operculum, fusiform and posteroinferor temporal region.
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