| Project/Area Number |
12671386
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
TERAMOTO Akira Nippon Medical School, Department of Neurosurgery, Professor, 医学部, 教授 (60231445)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SANNO Naoko Nippon Medical School, Department of Neurosurgery, Assistant Professor, 医学部, 講師 (90297862)
YOSHIDA Daizo Nippon Medical School, Department of Neurosurgery, Assistant Professor, 医学部, 講師 (30210701)
SHIMURA Toshiro Nippon Medical School, Department of Neurosurgery, Professor, 医学部, 助教授 (90110973)
|
|---|
| Project Period (FY) |
2000 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | incidentalomas / pituitary adenoma / Magnetic resonance imaging(MRI) / pituitary hormones / immunohistochemistry / transcription factors / non-functioning adenoma / 非機能性腺腫 / ゴナドトロピン / 下垂体機能低下 / MRI |
|---|
| Research Abstract |
The development of computed tomography (CT) and magnetic resonance imaging (MRI) has resulted in the discovery of unsuspected endocrinologically silent pituitary masses (pituitary incidentalomas). The aim of this study was to perfom a national survey on pituitary incidentalomas. A survey study was performed from 2000 to 2001. Five hundred and six patients with pituitary incidentalomas obtained Two hundred fifty-eight patients underwent surgery (surgical group), while 248 patients were followed up conservatively for a mean period of 26.9 months (range, 6 to 173 months) (non-surgical group). In thirty-three patients with pituitary incidentalomas (13.3%) developed tumor enlargement during the mean follow-up period of 45.5 months. In twenty-nine patients (12.0%), masses rather decreased in size. The mean age of patients who had increased mass and decreased mass were 54.7 years and 42.1 years, respectively. The common diagnosis of increased mass was non-functioning pituitary adenomas (23 patients, 69.7%) and macro tumors (17 patients, 51.5%). In non-surgical group, 23(20.2%) of 115 estimated non-functioning adenomas increased. Macroadenoma over 10 mm in diameter, solid mass, in older subjects tended to have enlargement. By immunohistochemistry, 46% of incidentally discovered adenomas were positive for one or more gonadotropin subunits.
|
