| Project/Area Number |
12671395
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
WATANABE Hideomi Gunma Univ., Orthopaedics, Associate Professor, 医学部, 助教授 (40231724)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAGISHI Kenji Gunma Univ., Orthopaedics, Professor, 医学部, 教授 (70154763)
SHINOZAKI Tetsuya Gunma Univ., Orthopaedics, Assistant Professor, 医学部, 講師 (90251115)
|
|---|
| Project Period (FY) |
2000 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | FDG / PET / musculoskeletal / AMF / PHI / GPI / hypoxia / glycolysis |
|---|
| Research Abstract |
In the present study, we elucidate the usefulness and the limit of FDG PET in the evaluation of musculoskeletal tumors. We tried other PET tracers, ^<18>F-alpha-methyl tyrosine and ^<11>C-choline for the tumor imaging and demonstrated their superiority to FDG. In schwannoma series only positive venous tumor staining at DSA correlated significantly with the degree of FDG accumulation, suggesting that the SUV for FDG reflects the degree of tumor vascularity in schwannomas. On the other hand, the pooling and cotton-wool staining depicted in DSA was found to be significantly correlated with FDG accumulation of hemangiomas, suggesting that localized blood retention-induced ischemia may accelerate anaerobic glycolysis which leads to high FDG uptake. Hypoxic condition has induced augmentation of AMF/PHI/GPI, which stimulated motile and metastatic capacities, suggesting a correlation of AMF augmentation and hypoxia related glycolysis activation. By the basic research the role of AMF/PHI/GPI and the receptor in the development of lung cancer. The signal transduction system of AMF/PHI/GPI stimulation involved the activation of integrin-beta, KIF3A, and GDI-beta by using adenovirus transfection system. The results obtained from the present investigations provide a new mechanisms involved in the progression of FDG-accumulated musculoskeletal tumors.
|
