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Biological study for osteoporosis -Apoptosis related gene expression-

Research Project

Project/Area Number 12671428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKagoshima University

Principal Investigator

IJIRI Kosei  Kagoshima University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (00315417)

Co-Investigator(Kenkyū-buntansha) TSUYAMA Shinichiro  Kagoshima University, Faculty of Medicine, Associate professor, 医学部, 助教授 (30041346)
MATSUNAGA Shunji  Kagoshima University, University Hospital, Faculty of Medicine, Assistant professor, 医学部附属病院, 講師 (90229500)
OHNISI Toshiyuki  Kagoshima University, University Hospital, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (60295243)
KOMIYA Setsuro  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (30178371)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsOsteoporosis / Apoptosis / sFRPs / Osteoporosis / Secreted related protein / 骨形態計測 / 分子生物学 / Monocyte / Secreted frizzled related protein
Research Abstract

In this study, bone histomorphometry has been performed using a rat model of osteoporosis. The relationship between bone mass and an account of osteoclast or its activity was observed and the possible role of osteoclast apoptosis in osteoporosis was suggested.
The gene expression and protein expression of Gas 6 was searched, however, neither of significant expressions was proved. Other genes, which related apoptosis were investigated in the method of differential display and secreted frizzled related protein (sFRP, 1,4,5) were detected as candidates for apoptosis related genes in bone.
SFRPs were overexpressed in the various condition of stimulation with INF, TGF or LPS. These genes are novel genes which might function in the pathway of Wnt signaling, however, there is few report on these proteins.
Conclusion: sFRPs were identified as candidates for apoptosis related gene in osteoporosis. Further investigation might be necessary for their functions in osteoporosis.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] K Ijiri: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"The Journal of Rheumatology. 29・11. 2266-2270 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] AM Malfait: "Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradaton in osteoarthritic cartilage"The Journal of Biological Chemistry. 277・25. 22201-22208 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M Nakamura: "Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor β"Biochemical and Biophysical research Communication. 297. 1238-1244 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 井尻 幸成: "慢性関節リウマチ滑膜マクロファージに発現する遺伝子の検討-Differential Display法を用いて-"日本整形外科学会雑誌. 75・8. S1046 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 井尻 幸成: "RA滑膜組織に特異的に発現する遺伝子の検討"整形外科と災害外科. 50・4. 1126-1128 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K Ijiri: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"The Journal of Rheumatology. 29-11. 2266-2270 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Anne-Marie Malfait: "Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage"The Journal of Biological Chemistry. 277-25. 22201-22208 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M Nakamura: "Nitration and chrination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor β"Biochemical and Biophysical Research Communication. 297. 1238-1244 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K Ijiri: "Osteocyte apoptosis of rheumatoid arthritis -involvement of mouse osteocyte-"The Journal of the Japanese Orthopaedic Association. 75-8. S1046 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K Ijiri: "Specific gene expression in RA synovium -differential display-"Orthopedics & Traumatology. 50-4. 1126-1128 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Ijiri: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"The Journal of Rheumatology. 29・11. 2266-2270 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Nakamura: "Nitration and chlorination of folic acid by peroxynitrite and hypochiorous acid, and the selective binding of 10-nitro folate to folate receptor β"Biochemical and Biophysical Research Communication. 297. 1238-1244 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Anne-Marie Malfait: "Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage"The Journal of Biological Chemistry. 277・25. 22201-22208 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 井尻幸成 他: "慢性関節リウマチ滑膜マクロファージに発現する遺伝子の検討-Differential Display法を用いて-"日本整形外科学会雑誌. 75(8). 1046 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 井尻幸成 他: "RA滑膜組織に特異的に発現する遺伝子の検討"整形外科と災害外科. 50(4). 1126-1128 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 井尻幸成 他: "RA滑膜組織に発現する遺伝子の検討-Differential Display法を用いて-"整形外科と災害外科. (In press).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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