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The role of Tumor Necrosis factor in radicular pain

Research Project

Project/Area Number 12671431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionFukushima Medical University

Principal Investigator

YABUKI Shoji  Fukushima Medical University, Department of Orthopaedic Surgery, Assistant Professor, 医学部, 講師 (00260779)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Shinichi  Fukushima Medical University, Department of Orthopaedic Surgery, Professor, 医学部, 教授 (80045773)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordstumor necrosis factor / radicular pain / disc herniation / compartment syndrome
Research Abstract

It has been shown using herniated nucleus pulposus model that application of pentoxifylline, an anti-TNF drug, with nucleus pulposus can prevent the increase of endoneurial fluid pressure (EFP) in the rat dorsal root ganglia (DRG) in 2000.
The purpose of the study in 2001 is to clarify whether application of TNF to the nerve root induces abnormal discharges in rat dorsal horn neurons or not, and to clarify the effects of lidocaine which used in nerve root block for treating the radicular pain on the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model.
The results were following; 1) TNF induced abnormal discharges in rat dorsal horn neurons, and 2) lidocaine prevented the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model. The result 1) suggests that TNF plays an important role to induce radicular pain. Also, the result 2) may show a mechanism of the therapeutic effect nerve root block.
In the 2001 studies, it is shown that TNF plays an important role to induce radicular pain, and nerve root block is an useful method for treating the radicular pain.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Shoji YABUKI: "Prevention of compartment syndrome in dorsal root ganglia caused by exposure to nucleus pulposus"Spine. 26. 870-874 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tamaki IGARASHI: "Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology"Spine. 25. 2975-2980 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Onda: "Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus"Spine. 26. 2186-2192 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira Onda: "Exogenous tumor necrosis factor induces abnormal discharges in rat dorsal horn neurons"Spine. 27(accepted). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Igarashi T, Kikuchi S, Shubayeb V, Myers RR: "Exgenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology"Spine 25. 2975-2980 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onda A, Hanaba M, Yabuki S, Kikuchi S: "Exogenous tumor necrosis factor induces abnormal discharges in rat dorsal horn neurons"Spine. (accepted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Onda A, Yabuki S, Kikuchi S, Satoh K, Myers RR: "Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus"Spine 26. 2186-2192 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yabiki S, Onda A, Kikuchi S, Myers RR: "Prevention of compartment syndrome in dorsal root ganglia caused by exposure to nucleus pulposus"Spine 26. 870-874 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Akira ONDA: "Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus"Spine. 26. 2186-2192 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akira ONDA: "Exogenous tumor necrosis factor induces abnormal discharges in rat dorsal horn neurons"Spine. 27(accepted). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shoji YABUKI: "Prevention of compartment syndrome in dorsal root ganglia caused exposure to nucleus pulposus"Spine. 26(accepted). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tamaki IGARASHI: "Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology"Spine. 25. 2975-2980 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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