The mechanism of destruction of bone and cartilage in rheumatoid arthritis.
| Project/Area Number |
12671442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | JIKEI UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
TUJI Michiko Jikei University, School of Medicine, Department of Orthopaedic Surgery, Lecturer, 医学部, 講師 (80207365)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Yutaka Jikei University, School of Medicine, Department of Orthopaedic Surgery, Research Assistant, 医学部, 助手 (30333066)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | OCIF / ODF / Rheumatoid arthritis / Collagen induced arthritis |
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| Research Abstract |
Rheumatoid arthritis (RA) is an enigmatic and incurable disease. Although RA is considered to be an autoimmune disease, its aetiology remains unknown. Therefore, RA presents both diagnostic and therapeutic difficulties to the physician. Here we show strong evidence that RA does not primarily involve the synovial membrane as previously believed, which may allow for the development of a specific treatment for the disease in the future.
It is generally accepted that RA is a chronic inflammatory disease of synovium. The first events in the development of articular damage is the proliferation of synovial cells together with inflammation and vascular neoformation in stromaof synovial tissue. As the disease progresses, the proliferating synovial tissue extends over.the articular cartilage and erodes from the joint surface down to and including the subchondral bone. Eventually, small and large joints of patients are destroyed, deformed and ankylosed. These results suggest that OCIF play a crucial role in the pathogenesis of arthritic destruction in RA.
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Report
(3 results)
Research Products
(8 results)
