| Project/Area Number |
12671449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
TAKAHASHI Satoshi Hirosaki University, University Hospital, Senior Instructor, 医学部附属病院, 助手 (10236276)
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| Co-Investigator(Kenkyū-buntansha) |
KUSHIKATA Tetsuya Hirosaki University, University Hospital, Instructor, 医学部附属病院, 医員 (80250603)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Sleep / Anesthesia / Sleep Deprivation / Ketamine / Propofol / EEG / Cytokine / サーカデアンリズム / 正向反射 / インターロイキン-1 / 腫瘍壊死因子 |
|---|
| Research Abstract |
It is hypothesized that stimuli to enhance sleep may make the potency of anesthetics strong. To test the hypothesis, we studied the effect of sleep deprivation on the anesthetic potency. In the first study, rats were performed 4-h, 6-h, 8-h sleep deprivation. After the sleep deprivation, the animals were injected ketamine or propofol intraperitoneally. Then, the rats were measured the anesthetic time that was defined as the time between the loss of righting reflex. The anesthetic time after ketamine or propofol injection was significantly increased by 6-h and 8-h sleep deprivation. In the second study, the anesthetic potency of ketamine after 8-h sleep deprivation was determined by measuring electroencephalogram and electromyogram in rats. The result was the same as the first study. 8-h sleep deprivation significantly prolonged the anesthetic time and enhanced electroencephalogram slow wave activity during anesthesia. These results support the hypothesis that stimuli to enhance sleep may make the potency of anesthetics strong.
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