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Partial liquid ventilation as an anti-inflammatory treatment in ARDS

Research Project

Project/Area Number 12671454
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical & Dental University

Principal Investigator

NAKAZAWA Koichi  Tokyo Medical & Dental University, Anesthesiology, Associate Professor, 大学院・医歯学総合研究科, 助教授 (10207756)

Co-Investigator(Kenkyū-buntansha) MAKITA Koshi  MAKITA,Koshi, 大学院・医歯学総合研究科, 教授 (20199657)
YOKOYAMA Kuninori  YOKOYAMA,Kuninori, 大学院・医歯学総合研究科, 助手 (00014176)
横山 訓典  東京医科歯科大学, 大学院・医歯学総合研究科, 助手 (80133841)
内田 徳治郎  東京医科歯科大学, 医学部・附属病院, 講師 (40262183)
松沢 吉保  東京医科歯科大学, 医学部・附属病院, 助手 (90311654)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsARDS / Perflubron / Liquid ventilation / Partial liquid ventilation / Endotoxemia / perfluorocarbon / partial liquid ventilation
Research Abstract

To determine whether partial liquid ventilation (PLV) modified lung inflammatory response, we analyzed blood cytokine levels and cytokine mRNA expression in the lungs, using a rat model of endotoxemia. Thirty-six rats were allocated into one of four groups. The first group received conventional gas ventilation (CV group), the second group received 10 ml/kg perflubron intratracheally in combination with mechanical gas ventilation (PLV group), the third group received 20mg/kg Escherichia coli lipopolyssacharide (LPS) intravenously in combination with mechanical gas ventilation (LPS group), and the fourth group received PLV and LPS (PLAT+LPS group). Blood levels of TNF-α, IL-1β, IL-6, IL-10, INF-γ and IL-1 receptor antagonist were significantly increased in LPS and PLV+LPS groups. mRNA expression of pro-and anti-inflammatory cytokines in the lung tissue was also significantly increased in these groups. mRNA expression of IL-6 in PLV+LPS group was significantly increased in comparison with LPS group. Other cytokine mRNA expression including IL-10 and IL-1β was also potentiated in PLV+LPS group, however this was not significant. Our results suggest that PLV does not protect the lungs against inflammation in systemic endotoxemia in rats

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K: "Inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions"Intensive Care Medicine. 26. 764-769 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Makita K, Nakazawa K, Yokoyama K: "The relationship between airway pressure and the distribution of gas-liquid interface during PLV in the oleic acid lung injury model : F-19 magnetic resonance imaging study."Critical Care Medicine. 28(8). 2904-2908 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakazawa K, Yokoyama K, Matsuzawa Y, Makita K: "Pulmonary administration of prostacyclin (PGI2) during partial liquid ventilation in an oleic acid-induced lung injury : inhalation of aerosol or intratracheal instillation?"Intensive Care Medicine. 27. 243-250 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K: "PO2 and PCO2 of perfluorocarbon liquid during PLV : Their regional difference end their dependence on tidal volume and PEEP level"Intensive Care Medicine. 27. 36-41 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 竹内稚依, 中沢弘一, 横山訓典, 松沢吉保, 槙田浩史: "部分液体換気法施行時の呼気終末陽圧、一回換気量およびperflubron投与量がガス交換に与える影響"麻酔. 50. 116-121 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中沢弘一: "Partial liquid ventilation-ガス交換のメカニズムと問題点"蘇生. 21. 9-15 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K: "Inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions"Intensive Care Med. 26. 764-769 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Makita K, Nakazawa K, Yokoyama K: "The relationship between airway pressure and the distribution of gas-liquid interface during partial liquid ventilation in the oleic acid lung injury model : Fluorine-l9 magnetic resonance imaging study"Crit Care Med. 28(8). 2904-2908 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakazawa K, Yokoyama K, Matsuzawa Y, Makita K, Amaha K.: "Pulmonary administration of prostacyclin (PGI2) during partial liquid ventilation in an oleic acid induced lung injury : inhalation of aerosol or intratracheal instillation?"Intensive Care Med. 27. 243-250 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K: "Partial pressure of oxygen and partial pressure of carbondioxide of perfluorocarbon liquid during partial liquid ventilation : Their regional difference and their dependence on tidal volume and PEEP level"Intensive Care Med. 27. 36-41 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi C, Nakazawa K, Yokoyama K, Matsuzawa Y, Makita K.: "Effects of positive endoexpiratory pressure, tidal volume and perflubron doses on gas exchange during partial liquid ventilation"Masui. 116-121 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakazawa K.: "Partial liquid ventilation-the mechanisms of gas exchange and its limitation"Japanese J of Reanimatology. 21. 9-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita: "PO2 and PCO2 of perfluorocarbon liquid during PLV : Their regional difference and their dependence on tidal volume and PEEP level"Intensive Care Medicine. 27. 36-41 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 竹内稚依, 中沢弘一, 横山訓典, 松沢吉保, 槙田浩史: "部分液体換気法施行時の呼気終末陽圧、一回換気量およびperflubron投与量がガス交換に与える影響"麻酔. 50. 116-121 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakazawa K, Yokoyama K, Matsuzawa Y, Makita K, Amaha K: "Pulmonary administration of PGI2 during PLV in an oleic acid-induced lung injury : inhalation of aerosol or intratracheal instillation"Intensive Care Medicine. 27. 243-250 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中沢弘一: "Partial liquid ventilation-ガス交換のメカニズムと問題点"蘇生. 21. 9-15 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K: "Po2 and PCO2 of perfluorocarbon liquid during PLV : Their regional difference and their dependence on tidal volume and PEEP level"Intensive Care Medicine. 27. 36-41 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 竹内稚依, 中沢弘一, 横山訓典, 松沢吉保, 槙田浩史: "部分液体換気法施行時の呼気終末陽圧、一回換気量およびperflubron投与量がガス交換に与える影響"麻酔. 50. 116-121 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchida T, Yokoyama K,Nakazawa K,Makita K: "Inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions."Intensive Care Med. 26. 764-9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Uchida T,Makita K,Nakazawa K,Yokoyama K: "The relationship between airway pressure and the distribution of gas-liquid interface during partial liquid ventilation in the oleic acid lung injury model : Fluorine-19 magnetic resonance imaging study."Crit Care Med. 28. 2904-8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakazawa K,Yokoyama K,Matsuzawa Y,Makita K,Amaha K: "Pulmonary administration of prostacyclin (PGI2) during partial liquid ventilation in an oleic acid-induced lung injury : inhalation of aerosol or intratracheal instillation?"Intensive Care Med. 27. 243-50 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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