| Project/Area Number |
12671462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
DOI Matsuyuki Hamamatsu University School of Medicine, Intensive Care Unit, Assistant Professor, 医学部附属病院, 講師 (10155616)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Shigehito Hamamatsu University School of Medicine, Department of Anesthesiology and Intensive Care, Professor, 医学部, 教授 (30143176)
MORITA Koji Hamamatsu University School of Medicine, Surgical Center, Research Associate, 医学部附属病院, 助手 (30115513)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | depth of anesthesia / automatic infusion / electroencephalograph / auditory evoked potentials / target controlled infusion / Bispectral Index / Bispectral Indes |
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| Research Abstract |
The aim of this project was to develop automatic infusion systems which were able to control a sedative and an analgesic independently. We chose surface EEG variables and auditory evoked potentials as input signals to quantify levels of sedation and analgesia. We have performed following sub-studies to complete this project.
1) Development of target controlled infusion (TCI) systems for propofol and fentanyl
Using published pharmacokinetic models, we made up TCI systems which were able to control blood or effect site concentration of propofol and fentanyl independently.
2) Development of a computer system to integrate surface EEG variables and auditory evoked potentials
Bispectral Index (BIS) and auditory evoked potential index (AEPindex) were involved as numerical variables for surface EEG and auditory evoked potentials, respectively. BIS and AEPindex values were automatically recorded in the system.
3) Investigation of the interaction of propofol and fentanyl on EEG variables
We studied interaction of propofol and fentanyl on EEGs to develop an algorithm which could quantify level of sedation and analgesia independently.
4) Investigation of an algorithm to detect awareness using BIS and AEPindex
We could detect awareness more accurately using a combination of BIS and AEPindex
5) Effects of profound hypothermia on EEG variables
We investigated stability of EEG variables down to 22 degree centigrade. We found the AEPindex was most stable among the EEG variables studied during profound hypothermia.
In conclusions, we found that the combination of the surface EEG and auditory evoked potentials were useful to detect awareness more accurately, however the combination did not have enough ability to quantify level of analgesia.
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