| Project/Area Number |
12671479
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | KUMAMOTO UNIVERSITY |
|---|
Principal Investigator |
SHIMODA Osamu Kumamoto university school of medicine, Department of anesthesiology, associate professor, 医学部, 助教授 (40187480)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUWAHARA Tomohiro Kumamoto university school of medicine, Department of urology, senior stuff, 医学部, 助手 (90305003)
YOSHITAKE Atsusi Kumamoto university school of medicine, Department of anesthesiology, senior stuff, 医学部・附属病院, 助手 (80291540)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥2,700,000 (Direct Cost: ¥2,700,000)
|
|---|
| Keywords | hypertension animal / individual nociceptive threshold / anesthesia depth / nociception / analgesic potential / circulatory variances |
|---|
| Research Abstract |
1. Clinical studies
1) Pre-operative blood pressure and autonomic functions in 108 patients for elective surgery were compared with intra-operative circulatory variances and the anesthetic power (AP) which we proposed as new index to compare various anesthetic techniques. The AP did not show linear relationship to preoperative blood pressure. The AP showed significant linear correlation to frequency domain analysis of arterial blood pressure. Mean blood pressure variances during anesthesia induction was significantly correlated to pre-operative blood pressure, heart rate and amplitude of skin vasomotor reflex (SVmR). Mean blood pressure variances during surgery was significantly correlated to frequency domain analysis of heart rate fluctuation and arterial blood pressure.
2) Current perception threshold test showed that blood pressure control system would influenced on nociceptive thresholds of peripheral A-delta and C fibers.
3) The amplitude of SVmR is useful index for quantitative assessment of nociception.
2. Animal studies
1) The three species, spontaneously hypertension rat (SHR), Wister-kyoto rat (WKY) and Wister rat (WR), showed defferences in nociceptive thresholds each other, but no significant changes in post-operative development of hyperalgesia on planter of rat (Brennan model).
2) Surgical stenosis of abdominal aorta (proximal right renal artery) increased latency of heat stimulation. Serum renin and angiotensin II levels did not have linear correlation to nociceptive thresholds.
|
