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Basic research of the gene therapy of testicular tumor cell

Research Project

Project/Area Number 12671537
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKagawa University

Principal Investigator

KAMANO Hiroshi  Kagawa University, Health Center, Prof., 保健管理センター, 教授 (60284337)

Project Period (FY) 2000 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsA-myb / B-myb
Research Abstract

The myb family consists of three members, the c-myb protooncogene and myb related genes A-myb and B-myb, all of which encode nuclear sequence-specific DNA-binding protein. C-myb proteins is expressed at high levels in most hematopoietic precursor cells and plays a crucial role in the proliferation and differentiation of these cells.
In the presence of DNA antisense B-myb oligo the proliferation rate of cell was significantly decreased on the fourth day. In the presence of mismatched DNA antisense B-myb oligo the proliferation 'rate of cell was not decreased. In the other hand, in the presence of morpholino antisense B-myb oligo the proliferation rate of cell was significantly decreased. In the presence of mismatched morpholin antisense B-myb oligo the proliferation rate of cell was not decreased.

Report

(5 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Kamano H, Sizmann J, Trauth K et al.: "Functional analysis of B-myb gene Expression of B-myb, alternative Splicing of B-myb gene(exon9a), and heat shock element dependent trans activation of the human HSP70 promotor"The First Waterfront Symposium of Human Genom Science. 1. 25 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Okutani Y, Kitanaka A, Tanaka T, Kamano H: "Src directly tyrosine-phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway"oncogene. 20(45). 6643-6650 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kubota Y, Tanaka T, Kitanaka A, Ohnishi H, Okutani Y, Waki M, Ishida T, Kamano H: "Src transduces erythropoietin-induced differentiation signals through phosphatidylinositd 3-kinase"EMBOJ. 20(20). 5666-5677 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamano H: "Photodynamic effects of gallium-metal porphyrin on human leukemia cells in combination with high-brightness LED light"Transplant.Proc.. 32(7). 2442-2443 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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