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Immune regulation for renal cell carcinoma

Research Project

Project/Area Number 12671548
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionSapporo Medical University

Principal Investigator

TAKAHASHI Atsushi (2001-2002)  Sapporo Medical University School of Medicine, Assistant Professor, 医学部, 講師 (20274946)

柳瀬 雅裕 (2000)  札幌医科大学, 医学部, 助手 (80291558)

Co-Investigator(Kenkyū-buntansha) YANASE Masahiro  Sapporo Medical University School of Medicine, Senior Instructor, 医学部, 助手 (80291558)
TSUKAMOTO Taiji  Sapporo Medical University School of Medicine, Professor, 医学部, 教授 (50112454)
高橋 敦  札幌医科大学, 医学部, 助手 (20274946)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsRCC / cytokine / VEGF / FLT-3 / 樹状細胞 / FLT-3-ITD / FLT-3阻害薬 / FLT-3リガンド / 免疫療法 / RCC / IL-6
Research Abstract

1) Recent reports showed that vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) might be involved to defective function of dendritic cells, leading to poor prognosis due to failure of immunotherapy. To test hypothesis, we measured serum levels of VEGF and IL-6 in RCC patients. Patients with elevated levels of VEGF and IL-6 had worse prognosis, suggesting that these factors (VEGF and IL-6) might affect dendritic cell dysfunction.
2) Among various factors which induce and proliferation and differentiation of dendritic cells, we focused on FLT-3 ligand-FLT-3 pathway, because interestingly FLT-3 is expressed in RCC cell lines. FLT-3 ligand did not affect the cell growth in RCC cell lines in vitro. About 20-30% of acute myeloid leukemia patients show genetic mutations of FLT-3, which leads to constitutive activation of FLT-3 activity. We hypothesized a similar mechanism as cause of fFLT-3 expression in RCC. However, no mutation was seen in RCC cell lines, indicating other mechanism than known mutation of FLT-3. The protein kinase inhibitor SU5614 failed to inhibit the cell growth to RCC cell lines in vitro. However, FLT-3 might be still a new target for treating RCC patients.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Uchida K, Miyao N, Masumori N, Takahashi A, Oda T, et al.: "Recurrence of renal cell carcinoma more than 5 year after nephrectomy"International Journal of Urology. 9. 19-23 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 塚本泰司, 高橋 敦, 北村 寛: "腎細胞癌の診断と治療-最新の進歩"日本腎臓学会誌. 44. 779-785 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 塚本泰司: "New泌尿器科学"南江堂. 184-193 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 伊藤直樹, 塚本泰司: "Urologic Surgeryシリーズ 8 腎臓及び上部尿路癌に対する手術"メディカルレビュー社. 21-29 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchida K, Miyao N, Masumori N, Takahashi a, Oda T, Yanase M, Kitamura H, Itoh N, Sato M, Tsukamoto T: "Recurrence of renal cell carcinomoa more than 5 years after nephrectomy"Int.J.Urol.. 9. 19-23 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukamoto T, Takahashi A, Kitamura H: "Recent progress indiagnosis and treatment of renal cell carcinoma"Jpn.J.Nephrol.. 44. 779-785 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsukamoto T, Eds.by Nishizawa O, Matsuda T: "Renal tumor (renal cell carcinoma, Wilms tumor and renal angiomyolipoma), New Urology"Nankohdo Inc.. 184-193 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itoh N, Tsukamoto T, Eds.by Tsukamoto T, Yamaguchi O: "Throcoabdominal nephrectomy, Urologjc Surgery Series 8.Surgery for renal cell carcinoma and upper urinary cancer"Medical View Inc.. 21-29 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 塚本泰司, 高橋 敦, 北村 寛: "腎細胞癌の診断と治療-最近の進歩"日腎会誌. 44. 779-785 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uchida K, Miyao N, Masumori N, Takahashi A, et al.: "Recurrence of renal cell carcinoma more than 5 years after nephrectomy"International Journal of Urology. 9. 19-23 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sasamura H, Takahashi A, Miyao N, Yanase M, et al.: "Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma"British Journal Cancer. 86. 768-773 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oda T, Takahashi A, Miyao N, Yanase M, et al.: "Cell proliferation, apoptosis, angiogenesis and growth rate of incidentally found renal cell carcinoma"International Journal of Urology. 10. 13-18 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oda T, Miyao N, Takahashi A, et al.: "Growth rates of primary and metastatic lesions of renal cell carcinoma"International Journal of Urology. 8. 473-477 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchida K, Miyao N, Masumori N, Takahashi A, et al.: "Recurrence of renal cell carcinoma more than 5 years after nephrectomy"International Journal of Urology. 9. 19-23 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kobayashi K, Sato T, Sunaoshi K, Takahashi A, et al.: "Spontaneous regression of primary renal cellcarcinoma with inferior vena caval tumor thrombus"Journal of Urology. 167. 242-243 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sasamura H, Takahashi A, et al.: "Inhibitory effect on expression of angiogenic factors by antiangiogenic agents in renal cell carcinoma"Britishi Journal of Cnacer. 86. 768-773 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋 敦, 塚本泰司: "改訂 泌尿器悪性腫瘍治療ハンドブック"新興医学出版. 18-25 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hisataki T,Miyao N,Takahashi A,Tsukamoto T,Yanase M, et al.: "Risk factor for the development of bladder cancer after upper tract urothelial cancer"Urology. 55. 663-667 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 柳瀬雅裕: "表在性膀胱腫瘍に対するPirarubicin(THP),Epirubicin(EPI)膀胱内注入療法による再発予防効果"泌尿器外科. 13(9). 35-34 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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