Correlation of Vascular endothelial growth factor with metastasis of prostate cancer
| Project/Area Number |
12671563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nihon University |
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Principal Investigator |
HACHIYA Takahiko School of medicine, Department of Urology, Nihon University, Lecturer, 医学部, 助手 (40228482)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Kiyoki School of medicine, Department of Urology, Nihon University, Professor, 医学部, 教授 (70059301)
HIRANO Daisaku School of medicine, Department of Urology, Nihon University, Lecturer, 医学部, 助手 (40228804)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | Prostate cancer / Metastasis / VEGF / Progression / Risk factor of progression |
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| Research Abstract |
We evaluated the outcome following radical prostatectomy in Japanese men with clinically localized prostate cancer with special reference to vascular endothelial growth factor in order to provide information about long-term survival.
Seventy-eight otherwise healthy patients with clinically localized prostate cancer underwent radical prostatectomy. Immunohistochemical VEGF staining and labeling index were evaluated for statistical purposes. Treatment outcomes were measured in terms of PSA failure, clinical progression free survival and prostate cancer specific survival with special reference to VEGF. Cox proportional model was used to determine the most important factors including VEGF, which may influence progression prostate cancer specific-survival. Of the 78 patients, 25 had negative VEGF staining, 53 had positive VEGF.
In terms of PSA failure free survival, clinical progression free survival and prostate cancer specific-survival there was not a statistically significant difference between VEGF negative tumors and VEGF positive tumors. On Cox multivariate analysis, only tumor grade alone approached statistical significance. Cox multivariate analysis revealed that VEGF was not a statistically significant independent predictor of progression. VEGF was not significantly correlated with tumor extension, differentiation, progression and survival. Therefore VEGF expression was inadequate and failed to provide any additional prognostic information.
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Report
(3 results)
Research Products
(17 results)
