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Effect of HMG CoA reductase inhibitor on kidney allograft function

Research Project

Project/Area Number 12671565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

CHIKARAISHI Tatsuya  St. Marianna Univ. Sch. of Med., Dept. of Urol., Asistrant Professor, 医学部, 講師 (80261303)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsFluvastatin / Immunosupression / Mixed lymphocyte culture reaction / フルバスタチン / リンパ球混合培養 / 免疫抑制 / 高脂血症 / HMGCoARI
Research Abstract

We investigated the potential role of fluvastatin(FV) in mitogen induced or allogeneic lymphocyte proliferative reactions in vitro.
<Materials and methods> Human peripheral blood lymphocytes were co-cultured with I12, PHA, or allogeneic lymphocytes in microcultureplate. FV was administered to each well at a final concentration of 2, 10, 50, 100 and 150ng/ml. The uptake of 3H-labeled thymidine was counted to estimate lymphocyte proliferation.
<Results> FV did not suppress the IL2 induced lymphocyte proliferation with the CPM value of 6942.7 ± 912.2(FV=2ng/ml), 8493.7 ± 1967.3(FV=10ng/ml), 6482 ± 3126.7(FV=50ng/ml), 7976.3 ± 2063.9(FV=100ng/ml), 3903 ± 2591.4(FV=150ng/ml). FV did not suppress the PHA induced lymphocyte proliferation with the CPM value of 26930 ± 11448.6(FV=0), 31048.33 ± 7619.4(FV=2), 25309.7 ± 9573.4(FV=10), 31613 ± 8745.9(FV=50), 23643.3 ± 4605.2(FV=100), 14290.3 ± 8405.4(FV=150). FV did not suppress alogeneic stimulation test (responder A against inactivated stimulator B) with the CPM value of 9848.3 ± 4580.3(FV=0), 107640 ± 3659.3(FV=2), 10898.7 ± 888.3(FV=10), 7599.3 ± 1084.7(FV=50), 5140.3 ± 501.4(FV=100), 7257.7 ± 3945.9(FV=150), however, FV more than 50 ng/ml significantly suppressed the allogeneic stimulation test in a different combination of responder B against inactivated stimulator A with CPM value of 16202.2 ± 2733.8(FV=0), 17952.3 ± 5363.5(FV=2), 13898.3 ± 3033.6(FV=10), 9169 ± 3902.9(FV=50), 8170.3 ± 2598.9(FV=100), 7981.3 ± 2481.7(FV=150). <Conclusion> FV did not suppress the mitogen induced lymphocyte proliferation, however, may have suppressive effect on allogeneic lymphocyte stimulation.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 力石辰也, 佐藤裕子, 堤 久, 宮野佐哲, 松下知彦, 野澤資亜利, 岩太昇明, 高橋剛: "高脂血症治療薬フルバスタチンの免疫抑制効果の検討-第1報-"移植. 37. 193-197 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 力石辰也, 星野孝夫, 岩本晃明: "新規に腎移植を行なう際の準備・問題点と対応"臨床泌尿器科. 54. 511-517 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikaraishi T., Iwamoto T., Hoshino T., Makizumi K., Yanagisawa N., Furuhata S., Sasaki H., Kato K., Inoue M.: "Autologous blood transfusion for kidney transplant recipients"Transplantation Proceedings. 32. 1853-1854 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikaraishi T, Satoh Y, Tsutumi T, Miyano S, Matsushita T, Nozawa S, Iwamoto T and Takahashi G: "Effect of Fluvastatin, an HMG CoA reductase inhibitor, on lymphocyte proliferative reaction in vivo"Jpn. J. Transplantation. 37. 193-197 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikaraishi T, Hoshino T and Iwamoto T: "Newly Started kidney transplantation in inexperienced hospitals : preparation and problems"Jpn. J. Clin. Urol.. 54. 511-517 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikaraishi T, Iwamoto T, Hoshino T, Makizumi K, Yanagisawa N, Furuhata S, Sasaki H, Kato K and Inoue M: "Aulologous blood transfusion for kidney transplant recipients"Transplantation proceedings. 32. 1853-1854 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Chikaraishi T.,Iwamoto T.,Hoshino T.,Makizumi K.,Yanagisawa N.,Furuhata S.,Sasaki H.,Kato K.,and Inoue M.: "Autologous blood transfusion for kidney transplant recipients"Transplantation Proceedings. 32. 1853-1854 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 力石辰也,星野孝夫,岩本晃明: "新規に腎移植を行なう際の準備・問題点と対応"臨床泌尿器科. 54. 511-517 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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