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Study on fetal circulation using Doppler signal and pulse waveforms

Research Project

Project/Area Number 12671609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKyushu University

Principal Investigator

NAKANO Hitoo  Graduate School of Medical Sciences, Prof., 大学院・医学研究院, 教授 (40038766)

Co-Investigator(Kenkyū-buntansha) NAGATA Hideaki  Maternity and Perinatal Care Unit, Lecturer, 医学部附属病院, 助手 (70253408)
SATOH Shoji  Maternity and Perinatal Care Unit, Senior Lecturer, 医学部附属病院, 講師 (00225947)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordshuman fetus / descending aorta / pulse waveform / cardiac function / pulse pressure / isovolumetric contraction time / placental insufficiency / cardiocirculatory failure / ドプラ超音波 / 胎児心機能 / 収縮時相解析 / ドプラ超音波法 / 胎児収縮時相
Research Abstract

(1) Study on fetal isovolumetric contraction time: To study the fetal cardiac isovolumetric contraction time (ICT) in normal and complicated pregnancies with placental vascular disease, ICTs were measured in 160 normal fetuses and 55 complicated pregnancies. In normal pregnancy, the ICT remained constant with gestation and fetal heart rate. A strong correlation between prolonged ICT duration and abnormalities in the perinatal course, indicating that a prolonged fetal ICT predicts adverse outcome in the presence of placental vascular disease.
(2) Study on fetal pulse waveform in the descending aorta: Pulse waveforms of the fetal descending aorta were obtained using an echo-tracking system to clarify the gestational age-related changes and the usefulness for detecting cardiac dysfunction. Peak-systolic (PSD) and end-diastolic diameter (EDD), pulse amplitude (Amp) and Amp:EDD ratio, calculated from the pulse waveforms, were adopted for analysis. In 196 normal fetuses after 20 weeks, the PSD, EDD and Amp increased, and Amp:EDD ratio decreased linearly with advancing gestation. The 19 fetuses with suspected cardiac dysfunction were divided into healthy and altered cardiac function subgroups, according to the values of fractional shortening and preload index. Of these, 7 fetuses with cardiac dysfunction had significantly higher incidence of low Amp (p<0.01) and Amp:EDD ratio (p<0.001) than remaining 12 fetuses with normal cardiac function. The pulse waveform analysis in the fetal descending aorta proved useful for detecting fetal cardiac dysfunction in utero.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Fujita Y, et al.: "Aortic pulse waveforms for evaluating cardiac performance in the human fetus"Ultrasound in Medicine and Biology. 28. 1245-1250 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoh S, et al.: "Antenatal sonographic detection of vesicoureteral reflux : A case report"Fetal Diagnosis and Therapy. 17. 277-280 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoh S, et al.: "Spontaneous rupture of the renal pelvis during pregnancy : A case report and review of the literature"American Journal of Perinatology. 19. 189-195 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fukushima K, et al.: "Insulin-like growth factors (IGF) -related proteins at birth in a case of antenatally diagnosed Silver-Russell syndrome"Pediatric Research. 51. 323-327 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koga T, et al.: "A new and simple Doppler method for measurement of fetal cardiac isovolumetric contraction time"Ultrasound in Obstertrics and Gynecology. 18. 264-267 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita Y, et al.: "Doppler velocimetry in the adrenal artery in human fetuses"Early Human Development. 65. 47-56 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Fujita S. Satoh, T. Koga, A. Mori, H. Nakano: "Aortic pulse waveforms for evaluating cardiac performance in the human fetus"Ultrasound in Medicine and Biology. 28. 1245-1250 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoh S, Inatomi S, Kubota M, Suita S, Nakano M: "Antenatal sonographic detection of vesicoureteral reflux: A case report"Fetal Diagnosis and Therapy. 17. 277-280 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Satoh S, Okuma A, Fujita Y, Tanaka M, Nakano H: "Spontaneous rupture of the renal pelvis during pregnancy: A case report and review of the literature"American Journal of Perinatology. 19. 189-195 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fukushima K, Komatsu H, Matsumoto M, Kobayashi H, Tsukimori K, Satoh S, Nakano H: "Insulin-like growth factors (IGF)-related proteins at birth in a case of antenatally diagnosed Silver-Russell syndrome"Pediatric Research. 51. 323-327 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koga T, Athayde H, Trudinger B, Nakano H: "A new and simple Doppler method for measurement of fetal cardiac isovolumetric contraction time"Ultrasound in Obstetrics and Gynecology. 18. 264-267 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita Y, Satoh S, Nakano H: "Doppler velocimetry in the adrenal artery in human fetuses"Early Human Development. 65. 47-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujita Y, et al.: "Aortic pulse waveforms for evaluating cardiac performance in the human fetus"Ultrasound in Medicine and Biology. 28. 1245-1250 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koga T, Athayde N, Trudinger B, Nakano H: "A new and simple Doppler method for measurement of fetal cardiac isovolumetric contraction time"U1trasound in Obstetrics & Gynecology. 18. 264-267 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujita Y, Satoh S, Nakano H: "Doppler velocimetry in the adrenal artery in human fetuses"Early Human Development. 65. 47-55 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Satoh S, Fujita Y, Nakano H et al.: "Chronologic Change in Doppler Indices in the Umbilical and Middle Cerebral Arteries in the Japanese Fetus : JSUM Standardization Committee for Fetal Measurements"J Med. Ultrasound. 9・2. 73-78 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujita Y, Satoh S, Nakayama H, Taguchi T, Suita S, Nakano H: "In utero Evaluation and the Long-Term Prognosis of Living Infants with Cystic Hygroma"Fetal Diagnosis and Therapy. 16. 402-406 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T Koga,S Satoh,Y Fujita,H Nakano: "Fetal Cardiac Isovolumetric Contraction Time : Detection Using Doppler Ultrasound Cardiography"Journal of Medical Ultrasonics. Vol 27 No 8. 1031-1036 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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