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Prevalence of HPV infection in women from Okinawa: Is high-risk HPV infection a potential factor in carcinoma of the cervix?

Research Project

Project/Area Number 12671618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

KANAZAWA Koji  University of the Ryukyus Faculty of Medicine, Professor, 医学部, 教授 (50092680)

Co-Investigator(Kenkyū-buntansha) NAGAI Yutaka  University of the Ryukyus Faculty or Medicine, Assistant., 医学部, 助手 (70305209)
MAEHAMA Toshiyuki  The Ryukyu University Hospital, Associate Professor, 医学部・附属病院, 講師 (50157153)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsHPV / potential factor / carcinoma of the cervix / HPV infection / prevalence / cervical carcinoma / Okinawa
Research Abstract

[Objective]: To analyze the prevalence of human papillomavirus (HPV) infection in a large number of women with cytologically normal cervix and patients with dysplasia or carcinoma of the cervix from Okinawa.
[Methods]: From 1994 to 1999, in a total of approximately 4800 subjects, the swabbed cells from the cervix were smeared on glass-slides for light microscopy, and cell suspensions were made for HPV DNA assay. HPV DNA assay by PCR was performed independent of histologic examination. L1 consensus primer was employed for HPV DNA detection. For the HPV DNA positive samples, the PCR for identification of HPV types was performed using the primers including HPV type 16 and 18.
[Results]: 1) HPV DNA was positive in 10.6% (434/4078 cases) of cervical cytology-normal women and the detection rate of type 16/18 was only 3.0% (13/434 cases). 2) HPV DNA was positive in 64.2% (102/159 cases) of patients with cervical dysplasia and in 85.6% (415/485 cases) of those with cervical carcinoma. Type 16/18 was identified in 15.7% (16/102 cases) of the former group and in 31.3% (152/415 cases) of the latter. Thus, the positive rate of HPV DNA and of type 16/18 were.significantly higher in the dysplasia or carcinoma patients than in the cervix-normal women (p<0.001), and also significantly higher in the carcinoma patients than in the dysplasia (p<0.001).
[Conclusion]: It was strongly suggested that HPV, especially high-risk type HPV is a potential factor in the carcinogenesis of cervical carcinoma through this crosssectional analysis.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Maehama T, Kanazawa K, et al.: "Prevalence of HPV infection in cervical cytology-normal women in Okinawa, Japan, as determined by a polymerase chain reaction"Int J Gynecol Obstet. 69. 175-176 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagai Y, Maehama T, Kanazawa K, et al.: "Persistence of human papillomavirus infection after therapeutic conization for CIN 3: Is it an alarm for disease recurrence?"Gynecol Oncol. 79. 294-299 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagai Y, Maehama T, Kanazawa K, et al.: "Detection of human papillomavirus DNA in primary and metastatic lesions of carcinoma of the cenvix in women from Okinawa, Japan"Am J Clin Oncol. 24. 160-166 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 前濱俊之, 金澤浩二: "HPV感染の疫学と自然史"産婦実際. 49. 643-646 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maehama T, Kanazawa K, et al: "Prevalence of HPV infection in cervical cytology-normal women in Okinawa, Japan, as determined by a polymerase chain reaction"Int. J. Gynecol Obstet. 69. 175-176 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagai Y, Maehama T, Kanazawa K, et al.: "Persistence of human papillomavirus infection after therapeutic conization for CIN 3: Is it an alarm for disease recurrence?"Gynecol. Oncol.. 79. 294-299 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagai Y., Maehama T., Kanazawa K., et al: "Detection of human papillomavirus DNA in primary and metastatic lesions of carcinoma of the cervix in women from Okinawa, Japan."Am J. Clin. Oncol.. 24. 160-166 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maehama T, Kanazawa K et al.: "Prevalence of HPV infection in cervical cytology-normal women in Okinawa, Japan, as determined by a polymerase chain reaction."Int J Gynecol Obstet. 69. 175-176 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagai Y Maehama T, Kanazawa K et al.: "Persistence of human papillomavirus infection after therapeutic conization for CIN3 : is it an alarm for disease recurrence ?"Gynecol Oncol. 79. 294-299 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagai Y, Maehama T, Kanazawa K et al.: "Detection of human papillomavirus DNA in primary and metastatic lesions of carcinoma of the cervix in woman from Okinawa Japan."Am J Clin Oncol. 24. 160-166 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 前濱俊之, 金澤浩二: "HPV感染の疫学と自然史"産婦実験. 49. 643-646 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagai Y,Maehama T,Asato T,Kanazawa K: "Persistence of human papillomavirus infection after therapeutic conization for CIN 3 : Is it an alarm for disease recurrence?"Gyneologic Oncology. 79. 294-299 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maehama T,Asato T,Kanazawa K: "Prevalence of HPV infection in cervical cytology-normal women in Okinawa, Japan, as determined by a polymerase chain reaction."International Journal of Gynecology Obstetrics. 69. 175-176 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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