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Investigation on the pathogenesis of acute peripheral facial palsy caused by herpes simplex virus reactivation.

Research Project

Project/Area Number 12671644
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

FURUWA Yasushi  Hokkaido Univ., Grad. School of Med., Asso. Prof., 大学院・医学研究科, 助教授 (60261301)

Co-Investigator(Kenkyū-buntansha) SAWA Hirofumi  Hokkaido Univ., Grad. School of Med., Asso. Prof., 大学院・医学研究科, 助教授 (30292006)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsHerpes simplex virus / Varicella-zoster virus / Tumor necrosis factor-α / Antiviral drug / MRI / Anti-ganglioside antibodies / Peripheral facial palsy
Research Abstract

1. Anti-HSV antibody in patients with peripheral facial palsy.
The prevalence of antibodies to HSV among patients with Bell's palsy was significantly higher than the prevalence among those with VZV reactivation. VZV reactivation causes acute peripheral facial palsy in most patients who lack antibodies to HSV.
2. Herpes virus reactivation and serum tumor necrosis factor-α levels in atients with acute peripheral facial palsy.
Tumor necrosis factor-α(TNF-α) plays an important role in several inflammatory and infectious diseases. We evaluated serum TNF-α levels of 75 patients with acute peripheral facial palsy. The results indicate that serum TNF-α levels are not affected by HSV-1 or VZV reactivation in patients with facial palsy.
3. Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy.
We sought to determine the efficacy acyclovir-prednisone therapy for patients with HSV-1 reactivation. The results suggest that early diagnosis of HSV-1 reactivation by PCR and subsequent acyclovir-prednisone therapy do not improve recovery from facial palsy.
4. Detection of the anti-ganglioside antibodies in patients with acute peripheral facial palsy.
We examined 26 sera of the patients with history of over two episodes of acute facial nerve palsy for anti-ganglioside antibodtes. We detected anti-Ga1NAc-Gd1a-GD1a IgG antibody from 2 sera by ELISA method. No anti-ganglioside antibodes were detected by TLC. It is suggested that the anti-ganglioside antibody is not main pathogenesis of acute peripheral facial nerve palsy.
5. Herpes virus reactivation and gadolinium-enhanced magnetic resonance imaging in patients with facial palsy.
We studied 15 patients with acute peripheral facial palsy to compare virologic tests and gadolinium-enhanced MRI findings. The results suggest that the meatal fundus or the geniculate ganglion may be affected first by virus reactivation in patients with herpetic facial palsy.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] Furuta Y: "High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral facial palsy"Clinical Infectious Diseases. 30巻. 529-533 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Reactivation of varicella-zoster virus in delayed facial palsy after dental treatment and oro-facial surgery"Journal of Medical Virology. 62巻. 42-45 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Early diagnosis of zoster sine herpete and antiviral therapy for the treatment of facial palsy"Neurology. 55巻. 708-710 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohtani F: "A rapid strip assay for detection of in anti-herpes simplex virus antibodies : Application to prediction of varicella-zoster virus reactivatlon in patients with acute peripheral facial palsy"Journal of Medical Virology. 62巻. 37-41 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy"Auris Nasus Larynx. 28巻. S13-S17 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohtani F: "Herpes virus reactivation and serum tumor necrosis factor-α levels in patients with acute peripheral facial palsy"Auris Nasus Larynx. 28巻. S145-S147 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete"Journal of Clinical Microbiology. 39巻. 2856-2859 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki F: "Herpes Virus Reactivation and Gadolinium-Enhanced Magnetic Resonance Imaging in Patients with Facial Palsy"Otology and Neurotology. 22巻. 549-553 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Western blot analysis for diagnosis of Lyme disease in acute facial palsy"Laryngoscope. 111. 719-723 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral fecial palsy."Clin Infect Dis. 30. 529-533 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "Reactivation of varicella-zoster virus in delayed facial palsy after dental treatment and oro-facial surgery."J Med Virol. 62. 42-45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "Early diagnosis of zoster sine herpete and antiviral therapy for the treatment of facial palsy."Neurology. 55. 708-710 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohtani F.: "Rapid strip assay for detection of anti-herpes simplex virus antibodies: Application to prediction of varicella-zoster virus reactivation in patients with acute peripheral facial palsy."J Med Virol. 62. 37-41 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "Western blot analysis for diagnosis of Lyme disease in acute facial palsy."Laryngoscope. 111. 719-723 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy."Auris Nasus Larynx. 28. S13-S17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ohtani F.: "Herpes virus reactivation and serum tumor necrosis factor-α levels in patients with acute peripheral facial palsy."Auris Nasus Larynx. 28. S145-S147 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Suzuki F.: "Herpes viras reactivation and gadolinium-enhanced magnetic resonance imaging in patients with facial palsy."Otol Neurotol. 22. 549-553 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y.: "Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete."J Clin Micarobiol. 39. 2856-2859 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuta Y: "Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy"Auris Nasus Larynx. 28巻. S13-S17 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohtani F: "Herpes virus reactivation and serum tumor necrosis factor-α levels in patients with acute peripheral facial palsy"Auris Nasus Larynx. 28巻. S145-S147 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Furuta Y: "Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete"Journal of Clinical Microbiology. 39巻. 2856-2859 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki F: "Herpes Virus Reactivation and Gadolinium-Enhanced Magnetic Resonance Imaging in Patients with Facial Palsy"Otology and Neurotology. 22巻. 549-553 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Furuta Y: "Western blot analysis for diagnosis of Lyme disease in acute facial palsy"Laryngoscope. 111. 719-723 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "顔面神経麻痺とウイルス"耳鼻咽喉科領域感染症Q&A. 80-81 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "末梢性顔面神経麻痺症例における抗ボレリア抗体の検索"Facial Nerve Research. 21巻. 51-53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "VZV再活性化症例における唾液中VZV DNAの定量と抗ウイルス療法の効果"Facial Nerve Research. 21巻. 42-44 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大谷文雄: "再発性・交代性顔面神経麻痺症例における血清中抗ガングリオシド抗体の測定"Facial Nerve Research. 21巻. 49-50 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "向神経性ウイルスと顔面神経麻痺"CLIENT219顔面神経障害. 巻. 43-50 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "ヘルペスウイルス再活性化が疑われる耳疾患の場合、これを確定するにはいかなる検査を行うか"耳鼻咽喉科・頭頸部外科クリニカルトレンドPart3. 巻. 123-124 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 古田 康: "ベル麻痺"今日の耳鼻咽喉科・頭頸部外科治療指針. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Furuta Y: "High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral facial palsy."Clinical Infectious Diseases. 30巻. 529-533 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Furuta Y: "Reactivation of varicella-zoster virus in delayed facial palsy after dental treatment and oro-facial surgery."Journal of Medical Virology. 62巻. 42-45 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Furuta Y: "Early diagnosis of zoster sine herpete and antiviral therapy for the treatment of facial palsy."Neurology. 55巻. 708-710 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohtani F: "A rapid strip assay for detection of anti-herpes simplex virus antibodies : Application to prediction of varicella-zoster virus reactivation in patients with acute peripheral facial palsy."Journal of Medical Virology. 62巻. 37-41 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Furuta Y: "Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy."Auris Nasus Larynx. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohtani F: "Herpes virus reactivation and serum tumor necrosis factorlevels in patients with acute peripheral facial palsy."Auris Nasus Larynx. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Suzuki F: "Herpes Virus Reactivation and Gadolinium-Enhanced Magnetic Resonance Imaging in Patients with Facial Palsy."American Journal of Otology. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Furuta Y: "Western blot analysis for diagnosis of Lyme disease in acute facial palsy."Laryngoscope. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 古田康: "Bell麻痺におけるウイルスの役割"医学のあゆみ. 192巻. 860-861 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 古田康: "顔面神経麻痺とウイルス"JOHNS. 16巻. 391-394 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 古田康: "ベル麻痺に対する抗ウイルス療法"日本医事新報. 3962巻. 167-168 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 古田康: "向神経性ウイルスと顔面神経麻痺"CLIENT219顔面神経障害. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] 古田康: "Zoster sine herpete症例を疑う因子の解析"Facial Nerve Research. 20巻. 52-54 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大谷文雄: "当科におけるzoster sine herpete症例の診断"Facial Nerve Research. 20巻. 55-57 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 武市紀人: "顔面神経麻痺患者における前庭機能評価-Vestibular evoked myogenic potential (VEMP) を用いて-"Facial Nerve Research. 20巻. 65-67 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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