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The mechanism of development of nasal hypersensitivity: Role of T cell and approach to treatment

Research Project

Project/Area Number 12671657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionYamanashi Medical University

Principal Investigator

MATSUZAKI Zensei  Yamanashi Medical University, Department of otorlaryngology, Assistant professor, 医学部, 講師 (90283217)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Yoshitaka  Yamanashi Medical University, epartment of otorlaryngology, Professor, 医学部, 教授 (40169157)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsNasal allergy / Nasal hypersensitivity / Eosinophil infiltration / Mast cell / CD4+T cell / cell transfer / Th l / Th2 / RS virus infection / アレルギーモデルマウス
Research Abstract

The influence of T cell on the development of nasal hypersensitivity was studied.The nasal hypersensitivity against histamine and increased number of eosinophils infiltrated in the nasal mucosa was observed in the mice lacking lacking CD4+T cells or in the mice lacking mast cells, both of which had been transferred Th2 rich CD4+T cells of ovalbumin sensitized mice. The transfer of Thl cells specific for ovalbumin to ovalbumin sensitized mice also did not improve the nasal hypersensitivity. Thus, eosinophils and mast cell seem to be not always necessary for the induction of nasal hypersensitivity and Th2 cytokines but not Thl cytokine may be strongly involved for the induction.
In additional study, acute RSV infection enhances response to subsequent sensitization to ovalbumin and also strongly enhance the sensitivity of former sensitized mice. The production of Th2 cytokines, not only of Thl cytokines in these infected mice seems to be associated with the development of nasal hypersensitivity. However, in the study with IL-10 transgenic (TG) mice, which expressed a large amount of IL-10 in the nasal mucosa, viral replication in the respiratory tract after intranasal infection with RSV was significantly suppressed compared to those in non-TG mice. Although IL-10 is one of Th2 type cytokines and is known to have an anti-inflammatory function, IL-10 may contribute to the anti-viral defense and to reduction of nasal hypersensitivity under these condition. Thus, a variety of mechanisms may contribute to the development of nasal hypersensitivity and hyperresponsiveness induced by T cells.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 松崎 全成: "花粉症とウイルス感染"JOHNS. 18. 53-55 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡本 美孝: "ウイルス感染制御による予防"アレルギー・免疫. 9. 323-327 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ruan Y: "Suppressive effects of locally produced interleukin-10 in respiratory syncytial virus infection"Immunology. 104. 355-360 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松崎 全成: "上気道のウイルス感染と臨床症状の発現メカニズム"アレルギー・免疫. 8. 47-51 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡本 美孝: "上気道粘膜とウイルス感染"炎症と免疫. 9. 638-644 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡本 美孝: "神経ペプチドと鼻アレルギー"アレルギー科. 11. 407-412 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松崎 全成: "鼻粘膜過敏性獲得へのT細胞関与についての検討"日本耳鼻咽喉科学会会報. 103. 447 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡本 美孝: "寄生虫感染と鼻アレルギー"アレルギー科. 9. 58-63 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuzaki Z: "The influence of viral infection to pollinosis."JOHNS. 18. 53-55 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto Y: "Prevention by control of viral infection."Allergology & Immunolo:. 9. 323-327 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ruan Y: "Suppressive effects of locally produced interleukin 10 in respiratory syncytial virus infection."Immunology. 104. 355-360 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuzaki Z: "The influence of upper respiratory tract viral infection to clinical symptoms"Allergology & Immunology. 8. 47-51 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto Y: "The influence of viral infection to upper respiratory tract mucosa."Inflammation and Immunity. 9. 638-644 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto Y: "Role of neuropeptides in nasal allergy."Allergology. 11. 407-412 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuzaki Z: "Role ofT cell to nasal hypersensitivity."J Otolaryngol Jpn. 103. 447 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamoto Y: "Dose parasite infection protect against the development of nasal allergy ?"Allergology. 9. 58-63 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松崎 全成: "花粉症とウイルス感染"JOHNS. 18. 53-55 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岡本 美孝: "ウイルス感染制御による予防"アレルギー・免疫. 9. 323-327 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ruan Y: "Suppressive effects of locally produced interleukin-10 in respiratory syncytial virus infection"Immunology. 104. 355-360 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松崎 全成: "上気道のウイルス感染と臨床症状の発現のメカニズム"アレルギー・免疫. 8. 47-51 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岡本 美孝: "上気道粘膜とウイルス感染"炎症と免疫. 9. 638-644 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岡本 美孝: "神経ペプチドと鼻アレルギー"アレルギー科. 11. 407-412 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松崎全成: "鼻粘膜過敏性獲得へのT細胞関与についての検討"日本耳鼻咽喉科学会会報. 103. 447 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松崎全成: "アレルギー性鼻炎における鼻粘膜炎症の成立機序とその臨床的意義:T細胞からみて"日本鼻科学会誌. 38. 271 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岡本美孝: "鼻粘膜過敏症-好酸球の関与"アレルギー. 48. 569-571 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 岡本美孝: "ウイルス感染と鼻粘膜過敏症"アレルギー科. 7. 393-399 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松崎全成: "気道アレルギーとウイルス感染"治療. 81. 814-817 (1999)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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