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Analysis of expression mechanism of endostatin and angiostatin

Research Project

Project/Area Number 12671659
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MINETA Hiroyuki  Hamamatsu University School of Medicine, Dept of Otolaryngology, Associate Professor, 医学部, 助教授 (40190714)

Co-Investigator(Kenkyū-buntansha) BABA Satoshi  Hamamatsu University School of Medicine, Dept of Pathology, Associate Professor, 医学部, 助教授 (10242760)
MISAWA Kiyoshi  Hamamatsu University School of Medicine, Dept of Otolaryngology, Staff, 医学部・附属病院, 助手 (90334979)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsHead and Neck / Angiogenesis / Angiostafin / Endostatin / 頭頚部癌 / VEGF
Research Abstract

We reported tat endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in the primary tumor. Endogenous endostatin which may be upregulated by p53 gene dices not represent antiangiogenic phenotype of the primary tumor.
Endostatin inhibits iNOS activity, in thyroid anapiastic carcinoma, maxillary carcinoma, and lung carcinoma cell lines, 2. Inhibition of iNOS activity by endostatin may cause to antoangiogenesis.
We speculate a pathway of antiangiogic function of endostatin fron these results. Endostatin inhibits iNOS activity, leading to decrease of NO production in NOS expressed tumor cells. Loss of NO production may cause to antiangiogenesis through inhibition of VEGF and increase of p53 accumulation.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] H.Mineta: "Immunohistochemical analysis of small cell carcinoma in head and neck"Ann Otol Rhinol Laryngol. 110. 76-82 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Mineta: "Prognostic value of vascular endothelial growth factor (VEGF) expression in head and neck squamous cell carcinomas"Br J Cancer. 83. 775-781 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Takebayashi: "Loss of heterozeigosity of 18q chromosome in head and neck cancer cell lines"Cancer Res.. 60. 3397-3403 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Harada: "Soritary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis"Pathol Int. 50. 431-439 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Miura: "Phosphoglyceride crystal deposition disease"Pathol Int. 50. 992-998 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Hineta: "Vascular endothelial growth factor (VEGF) expression in tongue squamous cell carcinoma"Anticancer Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 峯田周幸: "CLIENT 21 No.20 薬物療法 外用薬"野村恭也 他. 138-143 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Mineta, K. Miura, S. Takebayashi, et al: "lmmunohistochemial analysis of small cell carcinoma in head and neck"Ann Otol Rhinol Laryngol. 110. 76-82 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Mineta, K, Miura, t. Ogino, et al: "Prognostic value of vascular endothelial growth factor (VEGF) expression in head and neck squamous cell carcinomas"Br J Cancer. 83. 775-781 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Takebayashi, H. Mineta, T Carely, et al: "Loss of heterozeigosity of 18q chromosome in head and neck cancer cell lines"Cancer Res. 60. 3397-3403 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Harada, K Miura, H Mineta, et al: "Soritary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis"Pathol Int. 50. 431-439 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K Miura, H Fukuda, H Mineta, et al: "Phosphoglyceride crystal deposition disease"Pathol Int. 50. 992-998 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Mineta, K. Miura, S. Takebayashi, et al: "Vascular endothelial growth factor (VEGF) expression in tongue squamous cell carcinoma"Anticancer Res. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Mineta et. al: "Prognostic value of VEGF in Head and neck squamous cell carcinomas"Br. J. Cancer. 83・6. 775-781 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] H. Mineta et. al: "VEGF expression correlates with prognosis in patients with tongue carcinoma"Anticancer Res.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Mineta et.al: "Prognostic value of VEGF in HNSCCs"Br.J.cancer. 83(6). 775-781 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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