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Integration of the otolish and semicircular canals on single vestibular neurons

Research Project

Project/Area Number 12671682
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionTokyo Medical University

Principal Investigator

UCHINO Yoshio  Tokyo Medical University, Medicine, Professor, 医学部, 教授 (00086555)

Co-Investigator(Kenkyū-buntansha) SATO Hitoshi  Tokyo Medical University Medicinem Assistant professor, 医学部, 講師 (80154087)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsvestibular nerve / semicircular canal / otolith / dizziness / icuiburium system / utricular nerve / saccular / linear accereation / 重力 / 平衡異常
Research Abstract

(1)Commissural effects in the otolith system. Exp Brain es. 136, 421-430, (2001). We examined whether otolith-catibated vestibular neurons received commissural inhibition from the contralateral otolithic macula orented in the same geometric plane. More than half of the utricular (UT)-activated vestibular neurons received mommissural inhibition from the contralateral UT nerve. Approximately 10% of saccular (SAC)-activated vcstibular neurons received commissural inhibition. The present findings suggest that many UT-activated vestibular neurons receive commissursal inhibition, which may provide a mcchanism for increasing the sensitivity of vestibular neurons to horizontal linear acceleration and lateral tilt of the head. Commissural inhibition in the SAC system was less prominent than in the UT system. (2) Convergence of the horizontal semicircular canal and otolith afferents on cat single vestibular neurons. Exp Brain es.140, 1-11(2001). We studied the convergence of two afferent pairs t … More o single vestibular neurons by selective stimulation of the horizontal semicircular canal (HC)and SAC nerves, and the HC and UT nerves in decerebrated cats. Of a total of 125 neurons activated by stimulation of the HC/SAC nerves, 17% received convergent inputs. About half of the convergent neurons were classified as vestibulospinal neurons. In 80 neurons studied by stimulation of the HC/UT nerves, both inputs converged in 15% neurons and more than half of which were vestibulospinal neurons. The percentages of HC/SAC and HC/UT convergence were half those of the posterior semicircular canal (PC), PC/SAC(33%)and PC/UT(33%) convergence, respectively. The convergent neurons receiving the HC and otolith inputs may contribute at least partly to the vestibulocollic reflex. (3) Otolith-activated vestibulothalamic neurons in cats.. Exp Brain es, 141, 415-424(2001). The components of the vestibular ascending pathway that transmit otolith information to the thalamus were studied electrophysiologically in anesthetized cats. Otolith inputs to these neurons were examined with selective stimulation of the UT or the SAC nerves. Most of the neurons (38/40)were antidromically activated by focal stimulation of the ventral part of the ipsilateral thalamus. Only three SAC-activated vestibulo-thalamic nuerons were antidromically activated by stimulation of the contralateral thalamus, in marked contrast to the UT-activated vestibulo-thalamic neurons. Less

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Uchino Y: "Commissural effects in the otolith system"Exp.Brain Res.. 136. 421-430 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang X: "Convergence of the horizontal semicircular canal and otolith afferents on cat single vestibular neurons"Exp.Brain Res.. 140. 1-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Meng H: "Otolith-activated vestibulothalamic neurons in cats"Exp.Brain Res.. 141. 415-424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 内野善生: "ネコの手術・実験法"日本生理学雑誌. 63. 271-316 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchino Y: "Otolith and semicircular canal inputs to single vestibular neuronr in cats"Biological Sciences in space. 15. 376-382 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchino Y: "Canal and otolith inputs to single vestibular neurons in cats."Arch ital Biol.. 138. 3-13 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ogawa Y: "Neuronal organization of the utricular macula concerned with innervation of single vestibular neurons in the cat"Neurosci Lett.. 278. 89-92 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zakir M: "Saccular and utricular influences on sympathetic nerve activities in cats."Exp Brain Res.. 134. 402-406 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sato H: "Convergence of posterior semicircular canaland saccular inputs in single vestibular nuclei neurons in cats."Exp Brain Res.. 131. 253-261 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kushiro K: "Saccular and utricular inputs to single vestibular neurons in cats."Exp Brain Res.. 131. 406-415 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Isu N: "Sacculo-ocular reflex connectivity in cats."Exp Brain Res. 262-268 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zakir M: "Convergence patterns of the posterior semicircular canal and utricular inputs in single vestibular neurons in cat."Exp Brain Res. 131. 253-261 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchino Y.: "Commissural effects in theotolith system."Exp Brain Res.. 136. 421-430 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Zhang X,: "Convergence of the horizontal semicircular canal and otolith afferents on cat single vestibular neurons."Exp Brain Res.. 140. 1-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Meng H: "Otolith-activated vertibuothanlamic neurons in cats."Exp Brain Res.. 141. 415-424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchino Y: "Otolith and semicircular canal inputs to single vestibular neurons in cats."Biolgical Sciences in space,. 15. 376-382 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uchino Y.: "Canal and otolith inputs to single vestibular neurons in cats"Arch ital Biol.. 138. 3-13 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ogawa Y.: "Neuronal organization of the utricular macula concerned with innervation of single vestibular neurons in the cat"Neurosci Lett.. 278. 89-92 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zakir M.: "Saccular and utricular influences on sympathetic nerve activities in cats"Exp Brain Res.. 134. 402-406 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato H.: "Convergence of posterior semicircular canal and saccular inputs in single vestibular nuclei neurons in cats"Exp Brain Res.. 131. 253-261 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kushiro K.: "Saccular and utricular inputs to single vestibular neurons in cats"Exp Brain Res.. 131. 406-415 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Isu N.: "Sacculo-ocular reflex connectivity in cats"Exp Brain Res.. 131. 262-268 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zakir M.: "Convergence patterns of the posterior semicircular canal and untricular inputs in single vestibular neurons in cat"Exp Brain Res.. 131. 253-261 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchino Y.: "Commissural effects in theotolith system"Exp Brain Res.. 136. 421-430 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zhang X.: "Convergence of the horizontal semicircular canal and otolith afferents on cat single vestibular neurons"Exp Brain Res.. 140. 1-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Meng H.: "Otolith-activated vestibulothalamic neurons in cats"Exp Brain Res.. 141. 415-424 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uchino Y.: "Otolith and semicircular canal inputs to single vestibular neurons in cats"Biological Sciences in space. 15. 376-382 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 内野善生: "ネコの手術・実験法"日本生理学雑誌. 63. 271-316 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 内野善生(分担執筆): "CLIENT 21 (臨床耳鼻咽喉科・頭頚部外科)"中山書店. 179-192 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Uchino: "Canal and otolith inputs to single vestibualr neurons in cats"Archives Italiennes de Biologie. 138. 3-13 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] H.Sato: "Convergence of posterior semicircular canal and saccular inputs in Single vestibualr nuclei neurons in cats"Exp Brain Res. 131. 253-261 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Kushiro: "Sacccular and utricular inputs to single vestibularneurons in cats"Exp Brain Res. 131. 406-415 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Isu: "Sacculo-ocular reflex connectivity in cats"Exp Brain Res. 131. 262-268 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Zakir: "Convergence patterns of the posterior semicircular canal and utricular inputs in single vestibular neurons in cats"Exp Brain Res. 132. 139-148 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Ogawa: "Neuronal organization of the utricular macula concerned with innervation of single vestibular neurons in the cat"Neurosci Lett. 278. 89-92 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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