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β-catenin abnormalities in pediatric malignant solid tumors

Research Project

Project/Area Number 12671738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionOsaka University

Principal Investigator

KUSAFUKA Takeshi  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (70263267)

Co-Investigator(Kenkyū-buntansha) OKADA Akira  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (40028569)
WASA Masafumi  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10240467)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsβ-catenin / childhood / hepatoblastoma / nephroblastoma / rhabdomyosarcoma / neuroblastoma / βカテニン / 小児固形腫瘍
Research Abstract

(1) To investigate implication of p-catenin in tumorigenesis of childhood maligmant solid tumors, gene alterations and protein expression patterns of β-catenin were analyzed.
(2) Beta-catenin gene alterations were detected in 77% of hepatoblastomas and 25% of nephroblastomas investigated, and all alterations were considered to have a serious effect on phosphorylation by GSK-3β.
(3) Apparent distinction was observed between hepatoblastoma and hephroblastoma in β-catenin alteration -patterns.
(4) Abnormal protein expression pattern, such as intense immunostaining in tumor cell nuclei, was uniformly observed in a subsets of tumors of different histological types.
(5) Such abnormal accumulation of β-catenin was detected in all hepatoblastomas, 40% of nephroblastomas and several rhabdomyosarcomas, suggesting a common involvement of β-catenin abnormalities in tumorigenesis of these tumors.
(6) In neuroblastoms, any β-catenin abnormalities were detected.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Udatsu Y.: "High frequency of β-catenin mutation Sn hepato-gastona"Pediatr Surg Int. 17. 508-512 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 宇田津有子: "肝芽腫におけるβ-カテニン標的遺伝子MMP-7の転写亢進に関する検討"日小外会誌. 37. 275-282 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 宇田津有子: "肝芽腫におけるAPC遺伝子及びβ-カテニン遺伝子の異常"小児外科. 32. 1066-1071 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Udatsu Y, Kusafuka T, Kuroda S, Miao J, Okada A: "High frequency of β-catenin mutations in hepatoblastoma"Pediatric Surg Int.. 17. 508-512 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Udatsu Y: "High frequency of β-calenin mutation in hepato ftas tomb"Pediatri Surg Int. 17. 508-512 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宇田津 有子: "肝芽腫におけるβカロチン標的遺伝子MMP-7の転写亢進に関する検討"日本外科誌. 37. 275-282 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 宇田津 有子: "肝芽腫におけるAPC遺伝子及びβカロチン遺伝子の異常"小児外科. 32. 1065-1071 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Udatsu Y: "High frequency of β-cafenin mutations in hepatoblastoma"Pediatr Sorg Int. (in press).

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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