| Project/Area Number |
12671758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
ISOGAI Noritaka Hospital, Kinki University, Assistant Professor, 医学部附属病院, 助教授 (90203067)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
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| Keywords | Polymer / tissue enginnering / chondrocyte / Tissue engineering |
|---|
| Research Abstract |
We have developed a model of human ear that can be formed in a tissue engineering manner by seeding chondrocytes onto the 3D polymer which has a shape of human ear.
The polymer scaffolds supported : growth of chondrocytes after the models were implanted in athymic nude mice. The constructs in vivo developed through vascularization, formed new cartilage with characteristic gene expression and protein synthesis, and maintained the shape of human ear. As additional studies proceed, this approach will clinically become important.
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