Usefulness of contrast-enhanced sonography in differentiating metastatic from nonmetastatic cervical lymph nodes in patients with cancer

• Project/Area Number: 12671831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 病態科学系歯学(含放射線系歯学)
• Research Institution: Nagasaki University
• Principal Investigator: YONETSU Koichi NAGASAKIUNIVERSITY, SCHOOL OF DENTISTRY, ASSOCIATE PROFESSOR, 歯学部, 助教授 (70167039)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Takashi NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, PROFESSOR, 歯学部, 教授 (30172406) ; TAKAGI Yukinori NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, INSTRUCTOR, 歯学部, 助手 (30295084) ; SUMI Misa NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, ASSISTANT PROFESSOR, 歯学部・附属病院, 講師 (90284702) ; 泉 雅浩 長崎大学, 歯学部・附属病院, 講師 (40212956)
• Project Period (FY): 2000 – 2001
• Project Status: Completed (Fiscal Year 2001)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000); Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: Doppler sonography / Metastatic lymph nodes / Echo-enhancing agent / 顎部リンパ節転移 / 頚部リンパ節転移

Research Abstract

In a prospective study, we compared power Doppler with and without contrast medium in the depiction of vascularity for the characterization of metastatic lymph nodes. We performed power-Doppler sonography before and after administration of an echo-enhancing agent (Lcvovist Schering AG, Berlin, Germany). On Doppler sonograms, vascular architecture of lymph nodes was categorized into three different patterns; hilar, parenchymal ,and no signal patterns. Power Doppler sonography showed characteristic features of parenchymal blood flow signal in most of mctastatic lymph nodes. The characterization of vascular patterns with unenhanced power Doppler sonography improved diagnostic accuracy compared with gray-scale sonography. The sludy enhanced with Levovist showed vascularity in some of no signal lymph nodes seen on the unenhanced study. CONCLUSION: The combination of grey mode and power Doppler produced even greater diagnostic accuracy, independent of the administration of echo-enhancing agent. The use of songraphic contrast agent may increase the diagnostic accuracy of power Doppler in the differential diagnosis of metastatic lymph nodes.

Research Products

• [Publications] Yonetsu K, Sumi M, Izumi M, Ohki M, Eida S, Nakamura T: "Contribution of Doppler sonogarphy blood flow information to the diagnosis of metastatic cervical nodes in patients with head and neck cancer : assessment in relation to anatomic levels of the neck"AJNR Am J Neuroradiol. 22. 163-169 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Yonetsu K., Sumi M., Izumi M., Ohki M., Eida S., and Nakamura T.: "Contribution of Doppler sonogarphy blood flow information to the diagnosis of metastatic cervical nodes in patients with head and neck cancer: assessment in relation to anatdmic levels of the neck"AJNR Am. J. Neuroradiol.. 22. 163-169 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Yonetsu K, Sumi M, Izumi M, Ohki M, Eida S, Nakamura T.: "Contribution of Doppler sonogarphy blood flow information to the diagnosis of metastatic cervical nodes in patients with head and neck cancer : assessment in relation to anatomic levels of the neck"AJNR Am J Neuroradiol. 22. 163-169 (2001)
• [Publications] Yonetsu K,Sumi M,Izumi M,Ohki M,Eida S,and Nakamura T.: "Contribution of Doppler sonogarphy blood flow information to the diagnosis of metastatic cervical nodes in patients with head and neck cancer : assessment in relation to anatomic levels of the neck"AJNR Am J Neuroradiol. 22. 163-169 (2001)