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The overall study of the pulp and periodontal ligament of replanted tooth - The change of sensory nerve and the development of root end filling material -

Research Project

Project/Area Number 12671858
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionIwate Medical University

Principal Investigator

KUBOTA Minoru  School of Dentistry, Professor, 歯学部, 教授 (10005100)

Co-Investigator(Kenkyū-buntansha) MINAMI Kiyotaka  School of Dentistry, Instructor, 歯学部, 助手 (10326697)
MATSUMOTO Norio  School of Dentistry, Assistant professor, 歯学部, 講師 (90048562)
KUDOU Yoshiyuki  School of Dentistry, Associate professor, 歯学部, 助教授 (10195464)
UEDA Masahiko  Taihei Chemical Ind. Co., Ltd. R & D Dept, Manager, 研究開発部, 課長代理
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsPlaster of Paris / Absorbable material / Tissue reaction / Tissue compatibility / 再植歯 / 根尖封鎖材 / 知覚神経 / 電気生理学的検討
Research Abstract

The nociceptive neurons responding to noxious stimuli of the tooth, oral mucous or facial skin were recorded in the ventral posteromedial nucleus (VPM), and the posterior thalamic group (PO) and the zona incerta (ZI) in the diencephalon. These neurons were classified into the low threshold mechanoreceptive neurons, wide dynamic range neurons and nociceptive-specific neurons. Functional segregation of these nociceptive neurons was not apparent within the nucleus or between nuclei.
The nociceptive neurons are also recorded at the trigeminal caudal nucleus and the reticular subnuclei in the medulla oblongata. These nurons were divided into three groups depending their response pattern, (1) neurons with a latency of less than 30 msec, (2) those with a latency of more than 30 msec and (3) those with both latency. The nociceptive neurones showed all these response pattern, but the low threshold mechanoreceptive (LTM) neurons responded with the pattern of (1) suggesting the input from A-fiber.
The composition and properties of experimental and commercial bone grafting gypsum was evaluated. The experimental bone grafting gypsum was revealed that was calcium phosphate hemihydrate. The arsenic concentration of experimental bone grafting gypsum was under the detection limit (0.2 ppm) and lower level than the other materials.
The biocompatibility of the experimental bone grafting gypsum was tested at the periapical portion of the replanted rat incisor. In the control group, the reinforced eugenol cement was filled as root end filling material. The cement was not absorbed until four weeks after operation and the inflammation was still observed until four weeks after operation. In the experimental group, the experimental bone grafting gypsum was filled as root end filling material. The experimental bone grafting gypsum was absorbed until two weeks after operation and the inflammation went out until four weeks after operation.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 工藤義之, 南 清隆, 橋本正則, 菊地正浩, 柳谷隆仁, 植田正彦, 久保田稔: "石膏系骨補填材料の試作および理工学的性質"日本歯科保存学雑誌. 45. 515-521 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 村田純一郎, 松本範雄: "ラットの三叉神経脊髄路核尾側核および網様亜核の侵害受容細胞に対する扁桃体条件刺激の抑制効果"岩手医科大学歯学雑誌. 27. 246-260 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kudou Yoshiyuki, Kubota Minoru: "Replantation with Intentional Rotation of a Vertically Perfectly Fractured Root Using Adhesive Resin Cement"Dental Traumatology. (In printing).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kudou Yoshiyuki et al.: "Trial Manufacture and Properties of bone Grafting Gypsum"The Japanese Journal of Conservative Dentistry. 45. 515-521 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kudou Yoshiyuki et al.: "Replantation with Intentional Rotation of a Vertically Perfectly Fractured Root Using Adhesive Resin Cement"Dental Traumatokogy. in printing.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 工藤義之, 南 清隆, 橋本正則, 菊地正浩, 柳谷隆仁, 植田正彦, 久保田稔: "石膏系骨補填材料の試作および理工学的性質"日本歯科保存学雑誌. 45・6. 515-521 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 村田純一郎, 松本範雄: "ラットの三叉神経脊髄路核尾側核および網様亜核の侵害受容細胞に対する扁桃体条件刺激の抑制効果"岩手医科大学歯学雑誌. 27・3. 246-260 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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