Effect of occlusal interferences on dopamine release of prefrontal cortex in rats
| Project/Area Number |
12671916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Osaka Dental University |
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Principal Investigator |
MAEDA Teruta Osaka Dental University, Dentistry, Associate Professor, 歯学部, 助教授 (10103110)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | occlusion / autonomic nerve response / stress / SDA |
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| Research Abstract |
We investigated the relationship between the change of occlusion and the autonomic nerve response. Seven healthy adult subjects without symptoms of oral function were measured blood pressure (tonometory), heart rate, body temperature, fingertip blood flow, oxygen saturation. All subjects rested in an upright position on the dental chair. A 21 gauge intravenous catheter was inserted, and blood samples at rest were collected. Hemodynamics and plasma catecholamine were used as indication of stress. They wore the stabilization sprint on the maxilla which was divided into three parts (anterior than the first premolar and posterior than the second premolar).
Immediately after wearing every combination of the sprints, the heart rate increased (p=0.053) compared with that in the resting condition, but blood pressure and fingertip blood flow did not change significantly. Five minutes after insertion of only an anterior part of sprint or an anterior and unilateral posterior parts of sprint, the plasma catecholamine were increased (p=0.1). The CV of R-R interval were changed during insertion of sprint, however, the large individual differences were statistically shown (p<0.000001).
The present data suggest that experimental shortened dental arch influenced the autonomic nerve response, but it was not impossible to demonstrate statistically. We continue the experiment with additional conditions for overcoming a fault in the experiment.
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Report
(3 results)
Research Products
(4 results)
