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Investigation of c-fos and preprodynorphin induced by noxicious stimulation on tooth

Research Project

Project/Area Number 12671922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

IGARI Toshirou  Tohoku University, School of Dentistry Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (10142994)

Co-Investigator(Kenkyū-buntansha) IWATSUKI Naofumi  Tohoku University, Graduate School of Dentistry, Professor, 大学院歯学研究科, 教授 (50004908)
MORI Shirou  Tohoku University, School of Dentistry Dental Hospital, Lecturer, 歯学部附属病院, 講師 (80230069)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsc-fos / noxiciou stimulant / tooth pain / preprodynorphin
Research Abstract

Most uncuarable pain in oral lesion occurred after chronic pulpitis or periodopntitis which present the symptom like the deafferention pain. So we start the research for c-fos, one of the cancer related gene, is known to present in the dorsal horn of the spinal cord and the special area of brain, as a new marker of those oral pain. Under light halothane anesthesia reveal a rat's upper jaw nerve (1)cut the upper jaw nerve (Model I), (2)Chronic constriction injury (CCI) model (Model II) (3)sealed with paraformaldehyde in rat's cisal tooth pulp, chronic pulpal tooth model (Model III)
Samples were taken each 30minite to 3hours, and each one week to 3 months.
After noxious stimulation, the numbers of the c-fos positive cell on the dorsal horn of C1 and C2 cervical cord, and trigeminal nucleus caudalis (TNC) were presented in the stimulated group. But it also revealed in the sham group. (p<0.001 ; between the all group at the same area).
These results don't indicate that the noxious stimulus induces the gene expression of c-fos on the dorsal horn and TNC.
The c-fos, therefore, is not useful biochemical index for the evaluation of pain expression on nerve level in our research.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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