| Project/Area Number |
12671933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
MURAKAMI Kenichiro Kyoto Univ, Faculty of Medicine, Assosiate Professor, 医学研究科, 助教授 (00174269)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Katsu Kyoto Univ, Faculty of Medicine, Associate Professor, 医学研究科, 助手 (90314202)
TSUBOI Yoichi Kyoto Univ, Faculty of Medicine, Associate Professor, 医学研究科, 講師 (60221420)
IIZUKA Tadahiko Kyoto Univ, Faculty of Medicine, Professor, 医学研究科, 教授 (80026921)
KIUCHI Tetsuya Kyoto Univ, Faculty of Medicine, Associate Professor, 医学研究科, 助教授 (40303820)
YAMAMURA Isao Kyoto Univ, Faculty of Medicine, Associate Professor, 医学研究科, 助手 (90332733)
上本 伸二 京都大学, 医学研究科, 助教授 (40252449)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Organ Transplant / Oral Health and Disease / Immunosuppuressant / Tacrolimus / Odontogenic infection / 生体肝移植 / 口腔管理 |
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| Research Abstract |
Recently the organ transplantations have been progressed in Japan. However there have no guideline for the dental and oral health management for pre- and post-transplant patients, especially in recipients under having immuno-suppresive agents. In this study, we tried to design the pre-transplant protocol for oral health and disease. Special attenion was paid for the management of chronic dental focus in an asymptomatic phase such as chronic apical periodontitis, gnanulative chronic inflammatory lesion, and common periodontitis.
Representative clinical cases were reported ; a case of dental infection followed with severe sepsis, another case had failed the pre-transplant management for dental surgical intervention, and experience of simultaneous tooth extraction immediate after living liver transplant in the operation room. Also, dental and oral examination for 10 recipient patients with liver post-transplant was carried out on long-term having immuno-suppuressive agent. There was about 2.5-times higher incidence of dental caries of deciduous teeth as compared with the average of the common Japanese. Nevertheless the patients seems not to be susceptibl to severe gingivitis. Cyclosporin-induced gingival hyperplasia was recognized in one of two patients, but there was no gingival hyperplasia in the remaing group who having tacrolimus. In addition the patients showed no disorder in teeth eruption but tended to demonstrate the malocclusion such as Angle class III, crowding in the upper dental arch or open bite. There findings suggest that the liver transplant recipient taking immunosuppresive agents for long-term could be at risk for various dental problems and oral disease.
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