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Change in expression of c-fos and c-jun gene family in carcinogenesis of the oral mucosa.

Research Project

Project/Area Number 12671951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionMiyazaki Medical College

Principal Investigator

SHIBA Ryosuke  Miyazaki Medical College, Department of Oral and Maxillofacial Surgery, Professor, 医学部, 教授 (00029977)

Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsprecancerous lesion / oral mucosa / c-fos / c-jun / immunohistochemistry
Research Abstract

It is difficult to differentiate which precancerous lesions are going to malignant tumors. To differentiate the precancerous lesions which are going to malignant tumors from those which remain not to be malignant, we studied the expression pattern of oncogenes, c-fos and c-jun, immunohistochemically about various oral lesions : squamous cell carcinoma, leucoplakia, lichen planus, papilloma, etc.
The clinical materials were fixed in 10% formalin, embedded in paraffin and cut in 5μ thickness by a microtome. After incubation with anti-c-Fos and c-Jun antibody, the sections were stained by rhodamine-conjugated IgG for c-Fos and by FITC-conjugated IgG for c-Jun at the same time, and observed by a fluorescent microscopy.
Stainability of the epithelial lesions was divided into c-Fos(+)/c-Jun(+), c-Fos(+)/c-Jun(-), c-Fos(-)/c-Jun(+) and c-Fos(-)/c-Jun(-).
c-Fos(+)/c-Jun(+) cells were observed beneath the keratinized layer and sporadically at the basal cell layer of the normal oral mucosa, leucoplakia and lichen planus lesions. C-Fos(+)/c-Jun(-) cells were detected in few cases of normal oral mucosa, but in the squamous cell carcinoma of infiltrative tendency, some parts of leucoplakia and lichen planus lesions with down growth tendency. C-Fos(-)/c-Jun(+) cells were observed scatteringly in the squamous cell carcinoma with frequent mitosis.
From the above findings it may be suggested that the lesions of leucoplakia and lichen plamus with c-Fos(+)/c-Jun(-) cells have a tendency to change into malignancy.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] R.Shiba et al.: "Prophylaxis of tumour recurrence and metastasis with…"Asian J Oral Maxillofac Surg. 15. 38-43 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Kaneko et al.: "Primary neck management among patients with cancer of the.."Head & Neck. 24. 582-590 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Kuroki et al.: "Detection of maternal-fetal microchimerism in the inflammatory.."Annals of the Rheumatic Diseases. 61. 1041-1046 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Kashima et al.: "Surface electromyographic evaluation of the asymptomatic…"CRANIO. 18. 86-91 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Satoh et al.: "A cephalometric study of the relationship between the level…"Brit Oral Maxillofac Surg. 37. 486-489 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Satoh et al.: "A cephalometric study of the stability of the base…"J Cranio Maxillofac Surg. 27. 358-363 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 芝 良祐(分担): "口腔外科学 第2版"松矢篤三・白砂兼光 編. 853(551-580) (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] R. Shiba et al.: "Prophylaxis of tumor recurrence and metastasis with."Asian J Oral Maxillofac Surg.. 15. 38-43 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Kaneko et al.: "Primary neck management among patients with cancer."Head & Neck. 24. 582-590 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Kuroki et al.: "Detection of maternal-fetal microchimerism in the Inflammatory."Annals of the Rheumatic Diseases. 61. 1041-1046 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Kashima et al.: "Surface electromyographic evaluation of the asymptomatic."CRANIO. 18. 86-91 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Satoh et al.: "A cephalometric study of the relationship between the levels."Brit J Oral Maxillofac Surg.. 37. 486-489 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Satoh et al.: "A cephalometric study of the stability of the base."J Cranio Maxillofac Surg.. 27. 358-363 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shiba R 他: "Propylaxis of tumor recurrence and metastasis with a mixtue ・・・"Asian J Oral Maxillofac Surg. 15(1). 38-43 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kuroki M 他: "Detection of maternal-fetal microchimerism in the inflammatory ・・・"Ann Rheum Dis. 61(12). 1041-1046 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kaneko S 他: "Primary neck management among patients with cancer of the ・・・"Head & Neck. 24(6). 582-590 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kashima K 他: "Surface electro-graphic evaluation of the asymptomatic human・・・"CRANIO. 18(1). 86-91 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kashima K 他: "Increased pain sensitivity of the upper extremities of ・・・"CRANIO. 17(4). 241-246 (1999)

    • Related Report
      2002 Annual Research Report
  • [Publications] 池村邦夫他: "口腔とその隣接領域の悪性腫瘍に関する多施設共同研究"日本口腔腫瘍学会. 10(2). 71-85 (1998)

    • Related Report
      2002 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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