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Development of Diopside-BMP compound implant for maxillofacial reconstraction cases

Research Project

Project/Area Number 12671966
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

YAJIMA Yasutomo  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, LECTURER, 歯学部, 講師 (10183667)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Tomohiro  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, 歯学部, 助手 (60328276)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsdiopside / rhBMP-2 / implant / hydroxyapatite / maxillofacial reconstraction / rhBMP2 / diopside / diopside-BMP複合インプラント
Research Abstract

Recovery of a chewing function for the case that jaw or a face was removed surgically by a malignant tumor is a theme to be very important from a respect of QOL. We have planed recovery of a function using dental implant for these cases. However, it is known that the success rate is low in the existing implant material so that it is used for a jaw bone of no good condition. Thus we pushed forward this study aiming at development of Diopside-BMP compound implant.
At frist using adult dogs, dental implants were placed into the mandibles of no good condition (for a wide bone defect, vascularized bone graft group and free bone graft group). As a result of having observed it about osteogenesis process around implants, in the vascularized bone graft group belonging to, build-up of new bone was seen from early stage, and the implant showed integration with a bone in authenticity. However, absorption of a bone condinued in free bone graft group, and remodeling were recognized from out side of cortical bon, new bone formation around implants could be recognized after long term. Next, in the experimental study of rabbits, the carrier experiment of rhBMP-2 was investigated. As a result, certain bone formation was provided early, and it was able to be recovered in original configuration mandibles by using atelocollagen sponge and a poly lactic acid-co-glycolic acid membrane.
Furthermore, we developed the implant which coating turned a HA film of about 1um into titanium core materials circumference. These were placed into the implant bony sockets that were formed by excess, and it became clear to integrate with bone early in comparison with titanium.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 古谷義隆: "血管柄付き再植骨内へのインプラント埋入後の骨形成過程に関する研究"日本口腔外科学会誌. 48(発行予定). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 矢島安朝: "口腔悪性腫瘍切除後に用いられた骨内インプラントの長期治療成績"歯界展望. 96. 100-101 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 山内智博: "超薄膜HAコーティングインプラントの骨形成過程に関する実験的研究"日本顎顔面インプラント学会誌. 1(発行予定). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 古谷義隆: "血管柄付き骨再植骨内へのインプラント埋入に関する検討"日本顎顔面インプラント学会誌. 1(発行予定). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuya Y: "Experimental studies on the osteogenesis process around dental implants in vascularized bone replantations"Japanese Journal of Oral and Maxillofacial Surgery. 48(in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yajima Y: "Long-term results of endsteal implants used for restortion of oral function after oncologic surgery"Dental Outlook. 96. 100-101 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamauchi T: "Experimental studies on osteogenesis process for super-HA-membrane implant"Japan Academy of Maxillofacial Implantology. 1(in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Furuya Y: "Investigation of osteogenesis process around implants in vascularized bone replantations"Japanese Journal of Oral and Maxillofacial Surgery. 1(in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 古谷義隆, 矢島安朝, 野間弘康: "血管柄付き再植骨内へのインプラント埋入後の骨形成過程に関する実験的研究"日本口腔外科学会誌. 48巻7号(予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasutomo YAJIMA,Hiroyasu NOMA et at.: "Systemic Inflammatory Response Syndrome and Postoperative Complications after Oral Cancer Surgery"The Bulletin of Tokyo Dental College. Vol.41 No.4. 187-194 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 矢島安朝,野間弘康: "口腔悪性腫瘍切除後に用いられた骨内インプラントの長期治療成績"歯界展望. Vol.96 No.6. 1336-1337 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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